Transposition of the great vessels natural History, complications & prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. ; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. ; Cafer Zorkun, M.D., Ph.D. ; Keri Shafer, M.D. ; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. 
Common complications of TGA include:
- Congestive heart failure
- Eisenmenger syndrome (irreversible and progressive pulmonary vascular obstructive disease)
- Pulmonary artery stenosis
- Coronary artery ostial obstruction (coronary ischemia)
- Rarely can lead to supravalvular aortic stenosis
- Aortic root dilation
- Aortic regurgitation
- Without treatment, 30% of infants die within the first week of life, 50% will die in the first month, 70% will die in the first 6 months and 90% of infants will die before the end of the first year.
- The prognosis for patients with D-TGA is generally excellent following surgical correction.
- Current survival rates are greater than 90%.
- The ASO has the best long-term survival and functional outcome.
- Studies have reported a >95% rate survival at fifteen to twenty-five years following discharge.
- The prognosis on simple d-TGA depends mainly on the presence of cardiac shunts such as FO, ASD, VSD, and DA.
- Presence of one or more of the above mentioned defects are present, blood will be mixed, allowing a small amount of oxygen to be delivered to the body, giving an opportunity to the newborn to survive long enough to receive corrective surgery.
- Gatzoulis MA, Walters J, McLaughlin PR, Merchant N, Webb GD, Liu P (October 2000). "Late arrhythmia in adults with the mustard procedure for transposition of great arteries: a surrogate marker for right ventricular dysfunction?". Heart. 84 (4): 409–15. doi:10.1136/heart.84.4.409. PMC 1729461. PMID 10995411.
- Hutter PA, Kreb DL, Mantel SF, Hitchcock JF, Meijboom EJ, Bennink GB (October 2002). "Twenty-five years' experience with the arterial switch operation". J. Thorac. Cardiovasc. Surg. 124 (4): 790–7. doi:10.1067/mtc.2002.120714. PMID 12324738.