Pseudouridine

Jump to navigation Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Pseudouridine (abbreviated Ψ) is the C-glycoside isomer of the nucleoside uridine, and it is the most prevalent of the over one hundred different modified nucleosides found in RNA.[1] Ψ is found in all species and in all classes of RNA except mRNA.[2] Ψ is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation.[3]

400px

References

  1. Hamma T, Ferré-D'Amaré AR (2006). "Pseudouridine synthases". Chem. Biol. 13 (11): 1125–35. doi:10.1016/j.chembiol.2006.09.009. PMID 17113994.
  2. Charette M, Gray MW (2000). "Pseudouridine in RNA: what, where, how, and why". IUBMB Life. 49 (5): 341–51. PMID 10902565.
  3. Ferré-D'Amaré AR (2003). "RNA-modifying enzymes". Curr. Opin. Struct. Biol. 13 (1): 49–55. PMID 12581659.