Tropomyosin kinase

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In enzymology, a tropomyosin kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + tropomyosin ADP + O-phosphotropomyosin

Thus, the two substrates of this enzyme are ATP and tropomyosin, whereas its two products are ADP and O-phosphotropomyosin.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:tropomyosin O-phosphotransferase. Other names in common use include tropomyosin kinase (phosphorylating), and STK.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • deBelle I, Mak AS (1987). "Isolation and characterization of tropomyosin kinase from chicken embryo". Biochim. Biophys. Acta. 925: 17&ndash, 26. PMID 3593768.
  • Montgomery K, Mak AS (1984). "In vitro phosphorylation of tropomyosin by a kinase from chicken embryo". J. Biol. Chem. 259: 5555&ndash, 60. PMID 6325440.
  • Watson MH, Taneja AK, Hodges RS, Mak AS (1988). "Phosphorylation of alpha alpha- and beta beta-tropomyosin and synthetic peptide analogues". Biochemistry. 27: 4506&ndash, 12. PMID 3166994.

External links

The CAS registry number for this enzyme class is 90804-56-1.

Gene Ontology (GO) codes