Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.
↑Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS (Jan 2001). "Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation". Current Biology. 11 (1): 44–9. doi:10.1016/S0960-9822(01)00002-1. PMID11166179.
Yamaguchi N, Fukuda MN (May 1995). "Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins". The Journal of Biological Chemistry. 270 (20): 12170–6. doi:10.1074/jbc.270.33.19551. PMID7744867.
Lu Q, Luduena RF (Jan 1994). "In vitro analysis of microtubule assembly of isotypically pure tubulin dimers. Intrinsic differences in the assembly properties of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers in the absence of microtubule-associated proteins". The Journal of Biological Chemistry. 269 (3): 2041–7. PMID8294455.
Paschal BM, Holzbaur EL, Pfister KK, Clark S, Meyer DI, Vallee RB (Jul 1993). "Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin". The Journal of Biological Chemistry. 268 (20): 15318–23. PMID8325901.
Huby RD, Carlile GW, Ley SC (Dec 1995). "Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells". The Journal of Biological Chemistry. 270 (51): 30241–4. doi:10.1074/jbc.270.51.30241. PMID8530437.
Marie-Cardine A, Kirchgessner H, Eckerskorn C, Meuer SC, Schraven B (Dec 1995). "Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase". European Journal of Immunology. 25 (12): 3290–7. doi:10.1002/eji.1830251214. PMID8566014.
Peters JD, Furlong MT, Asai DJ, Harrison ML, Geahlen RL (Mar 1996). "Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine". The Journal of Biological Chemistry. 271 (9): 4755–62. doi:10.1074/jbc.271.9.4755. PMID8617742.
Best A, Ahmed S, Kozma R, Lim L (Feb 1996). "The Ras-related GTPase Rac1 binds tubulin". The Journal of Biological Chemistry. 271 (7): 3756–62. doi:10.1074/jbc.271.7.3756. PMID8631991.
Vaillant AR, Müller R, Langkopf A, Brown DL (May 1998). "Characterization of the microtubule-binding domain of microtubule-associated protein 1A and its effects on microtubule dynamics". The Journal of Biological Chemistry. 273 (22): 13973–81. doi:10.1074/jbc.273.22.13973. PMID9593747.