Jump to navigation Jump to search
External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)n/an/a
PubMed searchn/an/a
View/Edit Human

Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTE gene.[1][2]


TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[2] TPTE is a primate-specific duplicate of the TPTE2 (TPIP) inositol phospholipd phosphatase;[3] TPTE itself is predicted to lack phosphatase activity.[4] TPTE and TPTE2 are the mammalian homologues to the subfamily of voltage sensitive phosphatases.


  1. Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE (Dec 2003). "The TPTE gene family: cellular expression, subcellular localization and alternative splicing". Gene. 323: 189–99. doi:10.1016/j.gene.2003.09.038. PMID 14659893.
  2. 2.0 2.1 "Entrez Gene: TPTE transmembrane phosphatase with tensin homology".
  3. Leslie NR, Yang X, Downes CP, Weijer CJ (January 2007). "PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration". Curr. Biol. 17 (2): 115–25. doi:10.1016/j.cub.2006.12.026. PMC 1885949. PMID 17240336.
  4. Chen, Mark J.; Dixon, Jack E.; Manning, Gerard (2017-04-11). "Genomics and evolution of protein phosphatases". Sci. Signal. 10 (474): eaag1796. doi:10.1126/scisignal.aag1796. ISSN 1945-0877. PMID 28400531.

Further reading

  • Antonarakis SE (1998). "10 years of Genomics, chromosome 21, and Down syndrome". Genomics. 51 (1): 1–16. doi:10.1006/geno.1998.5335. PMID 9693027.
  • Chen H, Rossier C, Morris MA, et al. (2000). "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.". Hum. Genet. 105 (5): 399–409. doi:10.1007/s004390051122. PMID 10598804.
  • Guipponi M, Yaspo ML, Riesselman L, et al. (2000). "Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21". Hum. Genet. 107 (2): 127–31. doi:10.1007/s004390000343. PMID 11030409.
  • Wu Y, Dowbenko D, Pisabarro MT, et al. (2001). "PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase". J. Biol. Chem. 276 (24): 21745–53. doi:10.1074/jbc.M101480200. PMID 11279206.
  • Guipponi M, Tapparel C, Jousson O, et al. (2002). "The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family". Hum. Genet. 109 (6): 569–75. doi:10.1007/s004390100607. PMID 11810268.