TGF beta 3
|Transforming growth factor beta-3|
|Locus:||Chr. 14 q24|
|Gene code:||HUGO code:TGFB3|
|Protein type:||TGF beta family|
|Functions:||cell differentiation, embryogenesis|
|Taxa expressing:||Homo sapiens; homologs: many metazoan phyla|
|Diseases:||Arrhythmogenic Right Ventricular Dysplasia 1|
Transforming growth factor-beta 3 (TGF-β3) is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily, which includes the TGF-β family, Bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), inhibins and activins.
TGF-β3 is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate. This is caused by failure of epithelial cells in both sides of the developing palate to fuse. TGF-β3 also plays an essential role in controlling the development of lungs in mammals, by also regulating cell adhesion and ECM formation in this tissue, and controls wound healing by regulating the movements of epidermal and dermal cells in injured skin.
- Herpin A, Lelong C, Favrel P (2004). "Transforming growth factor-beta-related proteins: an ancestral and widespread superfamily of cytokines in metazoans". Dev Comp Immunol. 28 (5): 461–85. PMID 15062644.
- Taya Y, O'Kane S, Ferguson M (1999). "Pathogenesis of cleft palate in TGF-beta3 knockout mice". Development. 126 (17): 3869–79. PMID 10433915.
- Dudas M, Nagy A, Laping N, Moustakas A, Kaartinen V (2004). "Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway". Dev Biol. 266 (1): 96–108. PMID 14729481.
- Kaartinen V, Voncken J, Shuler C, Warburton D, Bu D, Heisterkamp N, Groffen J (1995). "Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction". Nat Genet. 11 (4): 415–21. PMID 7493022.
- Bandyopadhyay B, Fan J, Guan S, Li Y, Chen M, Woodley DT, Li W (2006). "A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing". J Cell Biol. 172 (7): 1093–105. PMID 16549496.
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