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Salutaridine is an alkaloid that is present in the morphinian alkaloid pathway of opium poppy. Its precursor is the alkaloid (R)-reticuline. (R)-reticuline is converted to salutaridine by the enzyme salutaridine synthase. Salutaridine is converted to salutaridinol by the enzyme salutaridine reductase (SalR), with the reduction of NADPH to NADP+.