SP4 (gene)

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Sp4 transcription factor
PDB rendering based on 1va1.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Symbols SP4 ; HF1B; MGC130008; MGC130009; SPR-1
External IDs Template:OMIM5 Template:MGI HomoloGene2341
RNA expression pattern
File:PBB GE SP4 206663 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Sp4 transcription factor, also known as SP4, is a human gene.[1]


  1. "Entrez Gene: SP4 Sp4 transcription factor".

Further reading

  • Suske G (1999). "The Sp-family of transcription factors". Gene. 238 (2): 291–300. PMID 10570957.
  • Hagen G, Müller S, Beato M, Suske G (1993). "Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes". Nucleic Acids Res. 20 (21): 5519–25. PMID 1454515.
  • Hagen G, Dennig J, Preiss A; et al. (1995). "Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3". J. Biol. Chem. 270 (42): 24989–94. PMID 7559627.
  • Kalff-Suske M, Kunz J, Grzeschik KH, Suske G (1995). "Human Sp4 transcription factor gene (SP4) maps to chromosome 7p15". Genomics. 26 (3): 631–3. PMID 7607696.
  • Majello B, De Luca P, Hagen G; et al. (1995). "Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1". Nucleic Acids Res. 22 (23): 4914–21. PMID 7800480.
  • Rotheneder H, Geymayer S, Haidweger E (2000). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. PMID 10547281.
  • Nguyên-Trân VT, Kubalak SW, Minamisawa S; et al. (2000). "A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages". Cell. 102 (5): 671–82. PMID 11007485.
  • Lerner LE, Gribanova YE, Ji M; et al. (2001). "Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements". J. Biol. Chem. 276 (37): 34999–5007. doi:10.1074/jbc.M103301200. PMID 11438531.
  • Lerner LE, Gribanova YE, Whitaker L; et al. (2002). "The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or CRX". J. Biol. Chem. 277 (29): 25877–83. doi:10.1074/jbc.M201407200. PMID 11943774.
  • Lee DK, Suh D, Edenberg HJ, Hur MW (2002). "POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1". J. Biol. Chem. 277 (30): 26761–8. doi:10.1074/jbc.M202078200. PMID 12004059.
  • Wistow G, Bernstein SL, Wyatt MK; et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Davis W, Chen ZJ, Ile KE, Tew KD (2003). "Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors". Nucleic Acids Res. 31 (3): 1097–107. PMID 12560508.
  • Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
  • Hong J, Samudio I, Liu S; et al. (2004). "Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins". Endocrinology. 145 (12): 5774–85. doi:10.1210/en.2004-0686. PMID 15345676.
  • Phillips RJ, Tyson-Capper Née Pollard AJ, Bailey J; et al. (2005). "Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases". J. Clin. Endocrinol. Metab. 90 (6): 3479–90. doi:10.1210/jc.2004-1962. PMID 15788387.
  • Higgins KJ, Liu S, Abdelrahim M; et al. (2006). "Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins". Endocrinology. 147 (7): 3285–95. doi:10.1210/en.2006-0081. PMID 16574784.
  • Gao YQ, Danciger M, Ozgul RK; et al. (2007). "Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease". Mol. Vis. 13: 287–92. PMID 17356515.

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