Sodium-hydrogen antiporter 3

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Solute carrier family 9 (sodium/hydrogen exchanger), member 3
Symbols SLC9A3 ; MGC126718; MGC126720; NHE3
External IDs Template:OMIM5 Template:MGI HomoloGene55804
RNA expression pattern
File:PBB GE SLC9A3 207212 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Sodium-hydrogen antiporter 3 or Sodium-hydrogen exchanger 3 (NHE3) is an isoform of sodium-hydrogen antiporters. It is found in the nephron of the kidney and is primarily responsible for maintaining the balance of sodium.[1] [2]


Protein kinase C stimulates NHE3, while protein kinase A inhibits it. [3]

There is a specific protein functioning as an NHE3 regulator, sodium-hydrogen antiporter 3 regulator 1.


It is a solute carrier family 9 (sodium/hydrogen exchanger), member 3


It is encoded by the gene SLC9A3.


  1. VI. Mechanisms of Salt & Water Reabsorption
  2. "Entrez Gene: SLC9A3 Solute carrier family 9 (sodium/hydrogen exchanger), member 3".
  3. 852 Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 852

Further reading

  • McDonough AA, Leong PK, Yang LE (2003). "Mechanisms of pressure natriuresis: how blood pressure regulates renal sodium transport". Ann. N. Y. Acad. Sci. 986: 669–77. PMID 12763917.
  • Orlowski J, Kandasamy RA, Shull GE (1992). "Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins". J. Biol. Chem. 267 (13): 9331–9. PMID 1577762.
  • Brant SR, Yun CH, Donowitz M, Tse CM (1995). "Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3". Am. J. Physiol. 269 (1 Pt 1): C198–206. PMID 7631746.
  • Brant SR, Bernstein M, Wasmuth JJ; et al. (1993). "Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3". Genomics. 15 (3): 668–72. PMID 8096830.
  • Colombani V, Silviani V, Marteau C; et al. (1996). "Presence of the NHE3 isoform of the Na+/H+ exchanger in human gallbladder". Clin. Sci. 91 (2): 209–12. PMID 8795445.
  • Dudeja PK, Rao DD, Syed I; et al. (1996). "Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA". Am. J. Physiol. 271 (3 Pt 1): G483–93. PMID 8843774.
  • Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. PMID 8901634.
  • Yun CH, Lamprecht G, Forster DV, Sidor A (1998). "NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin". J. Biol. Chem. 273 (40): 25856–63. PMID 9748260.
  • Biemesderfer D, Nagy T, DeGray B, Aronson PS (1999). "Specific association of megalin and the Na+/H+ exchanger isoform NHE3 in the proximal tubule". J. Biol. Chem. 274 (25): 17518–24. PMID 10364184.
  • Mobasheri A, Golding S, Pagakis SN; et al. (1999). "Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts". Cell Biol. Int. 22 (7–8): 551–62. doi:10.1006/cbir.1998.0299. PMID 10452823.
  • Trujillo E, Alvarez de la Rosa D, Mobasheri A; et al. (1999). "Sodium transport systems in human chondrocytes. II. Expression of ENaC, Na+/K+/2Cl- cotransporter and Na+/H+ exchangers in healthy and arthritic chondrocytes". Histol. Histopathol. 14 (4): 1023–31. PMID 10506918.
  • Repishti M, Hogan DL, Pratha V; et al. (2001). "Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G159–63. PMID 11408268.
  • Malakooti J, Memark VC, Dudeja PK, Ramaswamy K (2002). "Molecular cloning and functional analysis of the human Na(+)/H(+) exchanger NHE3 promoter". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (3): G491–500. doi:10.1152/ajpgi.00273.2001. PMID 11841999.
  • Gekle M, Serrano OK, Drumm K; et al. (2002). "NHE3 serves as a molecular tool for cAMP-mediated regulation of receptor-mediated endocytosis". Am. J. Physiol. Renal Physiol. 283 (3): F549–58. doi:10.1152/ajprenal.00206.2001. PMID 12167607.
  • Kennedy DJ, Leibach FH, Ganapathy V, Thwaites DT (2003). "Optimal absorptive transport of the dipeptide glycylsarcosine is dependent on functional Na+/H+ exchange activity". Pflugers Arch. 445 (1): 139–46. doi:10.1007/s00424-002-0910-1. PMID 12397398.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Lee SH, Seok YS, Jung HH; et al. (2003). "Expression of mRNA transcripts of the Na+/H+ and Cl-/HCO3- exchanger isoforms in human nasal mucosa". Acta Otolaryngol. 122 (8): 866–71. PMID 12542207.
  • Inoue H, Nakamura Y, Nagita M; et al. (2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. 26 (2): 148–55. PMID 12576672.
  • Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.

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