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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)n/an/a
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Solute carrier family 23 member 1 is a protein that in humans is encoded by the SLC23A1 gene.[1][2][3]


The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2.[3]

See also


  1. Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (November 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochimica et Biophysica Acta. 1442 (2–3): 353–60. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.
  2. Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (May 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature. 399 (6731): 70–5. doi:10.1038/19986. PMID 10331392.
  3. 3.0 3.1 "Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1".

Further reading

  • Liang WJ, Johnson D, Jarvis SM (2001). "Vitamin C transport systems of mammalian cells". Molecular Membrane Biology. 18 (1): 87–95. doi:10.1080/09687680110033774. PMID 11396616.
  • Hogue DL, Ling V (July 1999). "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals". Genomics. 59 (1): 18–23. doi:10.1006/geno.1999.5847. PMID 10395795.
  • Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD (September 1999). "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function". Biochemical and Biophysical Research Communications. 262 (3): 762–8. doi:10.1006/bbrc.1999.1272. PMID 10471399.
  • Wang H, Dutta B, Huang W, Devoe LD, Leibach FH, Ganapathy V, Prasad PD (November 1999). "Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant". Biochimica et Biophysica Acta. 1461 (1): 1–9. doi:10.1016/S0005-2736(99)00182-0. PMID 10556483.
  • Daruwala R, Song J, Koh WS, Rumsey SC, Levine M (November 1999). "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2". FEBS Letters. 460 (3): 480–4. doi:10.1016/S0014-5793(99)01393-9. PMID 10556521.
  • Wang Y, Mackenzie B, Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA (January 2000). "Human vitamin C (L-ascorbic acid) transporter SVCT1". Biochemical and Biophysical Research Communications. 267 (2): 488–94. doi:10.1006/bbrc.1999.1929. PMID 10631088.
  • Erichsen HC, Eck P, Levine M, Chanock S (October 2001). "Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2)". The Journal of Nutrition. 131 (10): 2623–7. PMID 11584081.
  • Hediger MA (May 2002). "New view at C". Nature Medicine. 8 (5): 445–6. doi:10.1038/nm0502-445. PMID 11984580.
  • Maulén NP, Henríquez EA, Kempe S, Cárcamo JG, Schmid-Kotsas A, Bachem M, Grünert A, Bustamante ME, Nualart F, Vera JC (March 2003). "Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells". The Journal of Biological Chemistry. 278 (11): 9035–41. doi:10.1074/jbc.M205119200. PMID 12381735.
  • Liang WJ, Johnson D, Ma LS, Jarvis SM, Wei-Jun L (December 2002). "Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C [corrected]". American Journal of Physiology. Cell Physiology. 283 (6): C1696–704. doi:10.1152/ajpcell.00461.2001. PMID 12388072.
  • Boyer JC, Campbell CE, Sigurdson WJ, Kuo SM (August 2005). "Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells". Biochemical and Biophysical Research Communications. 334 (1): 150–6. doi:10.1016/j.bbrc.2005.06.069. PMID 15993839.
  • Erichsen HC, Engel SA, Eck PK, Welch R, Yeager M, Levine M, Siega-Riz AM, Olshan AF, Chanock SJ (February 2006). "Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery". American Journal of Epidemiology. 163 (3): 245–54. doi:10.1093/aje/kwj035. PMID 16357110.
  • Kang JS, Kim HN, Jung DJ, Kim JE, Mun GH, Kim YS, Cho D, Shin DH, Hwang YI, Lee WJ (March 2007). "Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane". The Journal of Investigative Dermatology. 127 (3): 698–706. doi:10.1038/sj.jid.5700572. PMID 17008880.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.