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E number{{#property:P628}}
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Molar mass367.481

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Phenoperidine, marketed as its hydrochloride as Operidine or Lealgin, is an opioid used as a general anesthetic. It is a derivative of isonipecotic acid, like pethidine, and is metabolized in part to norpethidine. It is 20-200 times as potent as pethidine as an analgesic.

In humans 1 milligram is equipotent with 10 mg morphine. It has less effect on the circulatory system and is less hypnotic than morphine, but it has about the same emetic effect. The nausea can be prevented by giving droperidol or haloperidol. After an intravenous dose the analgesia sets in after 3-5 minutes.[1]

Phenoperidine shares structural similarities with both pethidine and haloperidol (and related butyrophenone antipsychotics, e.g. droperidol). While not commonly used today in clinical practice, it is of historical interest as a precursor in the development of some of the most widely used neuroleptic drugs on the market today.


  1. FASS (Farmacevtiska specialiteter i Sverige). 1983. ISBN 91-85314-44-7.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

External links

  • Kintz P, Godelar B, Mangin P, Lugnier A, Chaumont A (1989). "Simultaneous determination of pethidine (meperidine), phenoperidine, and norpethidine (normeperidine), their common metabolite, by gas chromatography with selective nitrogen detection". Forensic Sci Int. 43 (3): 267–73. PMID 2613140.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Claris O, Bertrix L (1988). "Phenoperidine: pharmacology and use in pediatric resuscitation". Pediatrie. 43 (6): 509–13. PMID 3186421.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • "Antipsychotics - Reference pathway". Kyoto Encyclopedia of Genes and Genomes. Kanehisa Laboratories, Kyoto University, University of Tokyo. Retrieved 2007-01-16.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Claris, O. and Bertrix L. "Phenoperidine: pharmacology and use in pediatric resuscitation". Pediatrie. 43 (6): 509–13.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

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