Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2gene.
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.
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Gervais C, Mauvieux L, Perrusson N, et al. (2005). "A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia". Leukemia. 19 (1): 145–8. doi:10.1038/sj.leu.2403565. PMID15496970.
Scott KK, Norris RA, Potter SS, et al. (2003). "GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein". DNA Cell Biol. 22 (2): 95–105. doi:10.1089/104454903321515904. PMID12713735.