PLATO bleeding criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

PLATO Bleeding Classification [1]

1. Major Life-threatening:

Other Major
  • Significantly disabling (eg, intraocular with permanent vision loss)
  • Associated drop in hemoglobin of 3 to 5 g/dL
  • Requiring transfusion of 2 to 3 U whole blood or PRBCs
Any Major
  • Any one of the above criteria

2. Minor

  • Requiring medical intervention to stop or treat bleeding (e.g., epistaxis requiring visit to medical facility for packing)

3. Minimal

  • All others (e.g., bruising, bleeding gums, oozing from injection sites) not requiring intervention or treatment


  1. Schulman S, Kearon C, Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis (2005). "Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients". J Thromb Haemost. 3 (4): 692–4. doi:10.1111/j.1538-7836.2005.01204.x. PMID 15842354.

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