Osteoarthritis causes

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Osteoarthritis causes

Osteoarthritis Microchapters


Patient Information


Historical Perspective




Differentiating Osteoarthritis from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

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Medical Therapy


Primary Prevention

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Cost-Effectiveness of Therapy

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou [2] Robert G. Badgett, M.D. [2] Luke Rusowicz-Orazem, B.S.; , Irfan Dotani [4]


Osteoarthritis (OA) is a result of a variety of disorders that lead to structural and functional failure in involved joints. Osteoarthritis, traditionally, has been considered as a disease specifically related to articular cartilage. Presently, it's been proven that OA influencing the whole joint system consisted of capsule, and synovium, subchondral bone, cartilage, menisci, ligaments, and periarticular muscle[1][2].


Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic Paget disease
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine Acromegaly, Hemochromatosis, hyperparathyroidism, Pituitary cancer, Pituitary tumors, Reduced sex hormones
Environmental No underlying causes
Gastroenterologic Hemochromatosis, Wilson disease
Genetic Adam12, Alkaptonuria  , Asymmetric leg length, Bmp, Clip, Col11a2, Ehlers-danlos syndrome, Erg, Familial chondrocalcinosis, Frzb, Gdf5, Il10, Larsen syndrome  , Mcf2l, Mmp3, Multiple epiphyseal dysplasia  , Nail-patella syndrome  , Osteochondritis dissecans  , Spondyloepiphyseal dysplasia tarda  , Tgfb1, Thalassemia, Wilson disease
Hematologic Diabetes, Hemochromatosis, Thalassemia
Iatrogenic Meniscectomy, Surgery
Infectious Disease Syringomyelia, Tabes dorsalis, Viral hepatitis
Musculoskeletal/Orthopedic Aseptic necrosis of bone, Asymmetric leg length, Avascular necrosis, Chondrocalcinosis 1  , Chondrocalcinosis 2, Developmental dysplasia of the hip, Ehlers-danlos syndrome, Familial chondrocalcinosis, Fracture of bone, Joint injury, Meniscectomy, Multiple epiphyseal dysplasia  , Muscle dysfunction, Osteochondritis dissecans  , Syringomyelia, Tabes dorsalis
Neurologic No underlying causes
Nutritional/Metabolic Diabetes, Obesity
Obstetric/Gynecologic No underlying causes
Oncologic Pituitary cancer, Pituitary tumors
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy Allergies, Aseptic necrosis of bone, Avascular necrosis, Chondrocalcinosis 1  , Chondrocalcinosis 2, Crystal deposition, Gout, Lupus, Rheumatoid arthritis, Satoyoshi syndrome
Sexual No underlying causes
Trauma Developmental dysplasia of the hip, Fracture of bone, Joint injury, Physical trauma, Trauma
Urologic Alkaptonuria 
Miscellaneous Aging

===Causes in Alphabetical Order=== [3][4][5]


  1. Bennet D (March 1993). "Arthritis--its classification, pathogenesis and clinical relevance". Tijdschr Diergeneeskd. 118 Suppl 1: 19S–23S. PMID 8480308.
  2. Man GS, Mologhianu G (March 2014). "Osteoarthritis pathogenesis - a complex process that involves the entire joint". J Med Life. 7 (1): 37–41. PMC 3956093. PMID 24653755.
  3. Renberg WC (September 2005). "Pathophysiology and management of arthritis". Vet. Clin. North Am. Small Anim. Pract. 35 (5): 1073–91, v. doi:10.1016/j.cvsm.2005.05.005. PMID 16129133.
  4. Harari J (July 1997). "Clinical evaluation of the osteoarthritic patient". Vet. Clin. North Am. Small Anim. Pract. 27 (4): 725–34. PMID 9243778.
  5. Rychel JK (February 2010). "Diagnosis and treatment of osteoarthritis". Top Companion Anim Med. 25 (1): 20–5. doi:10.1053/j.tcam.2009.10.005. PMID 20188335.

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