Jump to navigation Jump to search
ICD-9 251.9
OMIM 601820 256450
DiseasesDB 8922
MeSH D046768

WikiDoc Resources for Nesidioblastosis


Most recent articles on Nesidioblastosis

Most cited articles on Nesidioblastosis

Review articles on Nesidioblastosis

Articles on Nesidioblastosis in N Eng J Med, Lancet, BMJ


Powerpoint slides on Nesidioblastosis

Images of Nesidioblastosis

Photos of Nesidioblastosis

Podcasts & MP3s on Nesidioblastosis

Videos on Nesidioblastosis

Evidence Based Medicine

Cochrane Collaboration on Nesidioblastosis

Bandolier on Nesidioblastosis

TRIP on Nesidioblastosis

Clinical Trials

Ongoing Trials on Nesidioblastosis at Clinical

Trial results on Nesidioblastosis

Clinical Trials on Nesidioblastosis at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Nesidioblastosis

NICE Guidance on Nesidioblastosis


FDA on Nesidioblastosis

CDC on Nesidioblastosis


Books on Nesidioblastosis


Nesidioblastosis in the news

Be alerted to news on Nesidioblastosis

News trends on Nesidioblastosis


Blogs on Nesidioblastosis


Definitions of Nesidioblastosis

Patient Resources / Community

Patient resources on Nesidioblastosis

Discussion groups on Nesidioblastosis

Patient Handouts on Nesidioblastosis

Directions to Hospitals Treating Nesidioblastosis

Risk calculators and risk factors for Nesidioblastosis

Healthcare Provider Resources

Symptoms of Nesidioblastosis

Causes & Risk Factors for Nesidioblastosis

Diagnostic studies for Nesidioblastosis

Treatment of Nesidioblastosis

Continuing Medical Education (CME)

CME Programs on Nesidioblastosis


Nesidioblastosis en Espanol

Nesidioblastosis en Francais


Nesidioblastosis in the Marketplace

Patents on Nesidioblastosis

Experimental / Informatics

List of terms related to Nesidioblastosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Nesidioblastosis is a controversial medical term for hyperinsulinemic hypoglycemia attributed to excessive function of pancreatic beta cells with an abnormal microscopic appearance.

Historical Perspective

The term was coined in the first half of the 20th century. The abnormal histologic aspects of the tissue included the presence of islet cell enlargement, islet cell dysplasia, beta cells budding from ductal epithelium, and islets in apposition to ducts.

By the 1970s, nesidioblastosis was primarily used to describe the pancreatic dysfunction associated with persistent congenital hyperinsulinism and in most cases from the 1970s until the 1970s, it was used as a synonym for what is now referred to as congenital hyperinsulinism. Most congenital hyperinsulinism is caused by different mechanisms than excessive proliferation of beta cells in a fetal pattern and the term fell into disfavor after it was recognized in the late 1980s that the characteristic tissue features were sometimes seen in pancreatic tissue from normal infants and even adults, and is not consistently associated with hyperinsulinemic hypoglycemia.

However, the term has been resurrected in recent years to describe a form of acquired hyperinsulinism with beta cell hyperplasia found in adults, especially after gastrointestinal surgery.[1][2][3]

Related Chapters


  1. Raffel A, Krausch M M, Anlauf M, Wieben D, Braunstein S, Klöppel G, Röher H, Knoefel W (2007). "Diffuse nesidioblastosis as a cause of hyperinsulinemic hypoglycemia in adults: a diagnostic and therapeutic challenge". Surgery. 141 (2): 179–84, discussion 185-6. PMID 17263973.
  2. Clancy T, Moore F, Zinner M (2006). "Post-gastric bypass hyperinsulinism with nesidioblastosis: subtotal or total pancreatectomy may be needed to prevent recurrent hypoglycemia". J Gastrointest Surg. 10 (8): 1116–9. PMID 16966030.
  3. Raffel A, Anlauf M, Hosch S, Krausch M, Henopp T, Bauersfeld J, Klofat R, Bach D, Eisenberger C, Kloppel G, Knoefel W (2006). "Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes". World J Gastroenterol. 12 (44): 7221–4. PMID 17131493.

Template:WikiDoc Sources