Myosin-heavy-chain kinase

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In enzymology, a myosin-heavy-chain kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + [myosin heavy-chain] ADP + [myosin heavy-chain] phosphate

Thus, the two substrates of this enzyme are ATP and [[[myosin heavy-chain]]], whereas its two products are ADP and myosin heavy-chain phosphate.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[myosin heavy-chain] O-phosphotransferase. Other names in common use include ATP:myosin-heavy-chain O-phosphotransferase, calmodulin-dependent myosin heavy chain kinase, MHCK, MIHC kinase, myosin heavy chain kinase, myosin I heavy-chain kinase, myosin II heavy-chain kinase, [myosin-heavy-chain] kinase, myosin heavy chain kinase A, and STK6.


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  • Cote GP, Bukiejko U (1987). "Purification and characterization of a myosin heavy chain kinase from Dictyostelium discoideum". J. Biol. Chem. 262: 1065&ndash, 72. PMID 3027076.
  • Hammer JA 3rd Albanesi JP, Korn ED (1983). "Purification and characterization of a myosin I heavy chain kinase from Acanthamoeba castellanii". J. Biol. Chem. 258: 10168&ndash, 75. PMID 6309772.
  • Rieker JP, Swanljung-Collins H, Collins JH (1987). "Purification and characterization of a calmodulin-dependent myosin heavy chain kinase from intestinal brush border". J. Biol. Chem. 262: 15262&ndash, 8. PMID 2822719.
  • Ravid S, Spudich JA (1989). "Myosin heavy chain kinase from developed Dictyostelium cells Purification and characterization". J. Biol. Chem. 264: 15144&ndash, 50. PMID 2549052.
  • Brzeska H, Lynch TJ, Martin B, Corigliano-Murphy A, Korn ED (1990). "Substrate specificity of Acanthamoeba myosin I heavy chain kinase as determined with synthetic peptides". J. Biol. Chem. 265: 16138&ndash, 44. PMID 2168881.
  • Ravid S, Spudich JA (1992). "Membrane-bound Dictyostelium myosin heavy chain kinase: a developmentally regulated substrate-specific member of the protein kinase C family". Proc. Natl. Acad. Sci. U. S. A. 89: 5877&ndash, 81. PMID 1321427.
  • Futey LM, Medley QG, Cote GP, Egelhoff TT (1995). "Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins". J. Biol. Chem. 270: 523&ndash, 9. PMID 7822274.
  • Korn ED, Brzeska H (1998). "Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinase". Proc. Natl. Acad. Sci. U. S. A. 95: 4146&ndash, 51. PMID 9539704.
  • Egelhoff TT, Croft D, Steimle PA (2005). "Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly". J. Biol. Chem. 280: 2879&ndash, 87. PMID 15545285.

External links

The CAS registry number for this enzyme class is 64763-54-8.

Gene Ontology (GO) codes