MAP kinase kinase kinase

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MAP kinase kinase kinase (or MAP3K or MEKK) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase.

There are 15 genes:

MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4).[1] MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway.[2] MAP3K7(TAK1)participate in regulation of transcription by transforming growth factor-beta (TGF-beta).[3]

External links


  1. Yan M; et al. (1994). "Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1". Nature. 372: 798–800.
  2. Ellinger-Ziegelbauer H; et al. (1997). "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative". J Biol Chem. 272: 2668–74.
  3. Yamaguchi K; et al. (1995). "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction". Science. 270: 2008–11.

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