Kawasaki disease history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2]


Kawasaki disease often begins with a high and persistent fever that is not very responsive to normal doses of acetaminophen or ibuprofen. The fever may persist and rise steadily for up to two weeks and is normally accompanied by irritability. Affected children develop redness of the eyes, mucous membranes, and lips, a "strawberry tongue", iritis, keratic precipitates (detected by an ophthalmologist but usually too small to be seen by the naked eye), and swollen lymph nodesSkin rash occur early in the disease, and peeling of the skin in the genital area, hands, and feet may occur in the later phases. Some of these symptoms may come and go during the course of the illness.

History and Symptoms

Symptoms of Kawasaki disease include a high and persistent fever, skin rashes, desquamation of skin, irritability, erythema of the eyes, lips, and mucous membranes, strawberry tongue, iritis, keratic precipitates, and swollen lymph nodes.[1]


Patients with Kawasaki disease may have a positive history of:

Common Symptoms

Strawberry tongue and bright red, swollen lips with vertical cracking and bleeding.[2]

Common symptoms of Kawasaki disease include:

Less Common Symptoms

Less common symptoms of Kawasaki disease include:


  1. McCrindle, Brian W.; Rowley, Anne H.; Newburger, Jane W.; Burns, Jane C.; Bolger, Anne F.; Gewitz, Michael; Baker, Annette L.; Jackson, Mary Anne; Takahashi, Masato; Shah, Pinak B.; Kobayashi, Tohru; Wu, Mei-Hwan; Saji, Tsutomu T.; Pahl, Elfriede (2017). "Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association". Circulation. 135 (17): e927–e999. doi:10.1161/CIR.0000000000000484. ISSN 0009-7322.
  2. By Kawasaki_symptoms.jpg: Dong Soo Kimderivative work: Natr (talk) - Kawasaki_symptoms.jpg, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=12776137

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