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Legal status
Legal status
  • In general: legal
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
Molar mass327.43 g/mol

JWH-015 is a drug from the aminoalkylindole family, which acts as a subtype-selective cannabinoid agonist. Its affinity for CB2 receptors is 13.8nM, while its affinity for CB1 is 383nM, meaning that it binds almost 28x more strongly to CB2 than CB1.[1] However it still displays some weak CB1 activity, and is not as selective as newer drugs such as JWH-133.[2]



  1. Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependance 2000; 60:133-140.
  2. Marriott KS, Huffman JW. Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor. Current Topics in Medicinal Chemistry. 2008;8(3):187-204. PMID 18289088

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