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ICD-9 286.3, 776.3
eMedicine ped/1133 
MeSH D007020

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List of terms related to Hypoprothrombinemia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Hypoprothrombinemia is a blood disorder in which a deficiency of prothrombin (Factor II) results in impaired blood clotting, leading to an increased physiological risk for bleeding, especially in the gastrointestinal system, cranial vault, and superficial integumentary system.


Hypoprothrombinemia can be the result of a genetic defect or it may be acquired as the result of another disease process, or an adverse effect of medication such as Sulfasalazine, aspirin. For example, 5-10% of patients with Systemic lupus erythematosus exhibit acquired hypoprothrombinemia due to the presence of autoantibodies which bind to prothrombin and remove it from the bloodstream (lupus anticoagulant-hypoprothrombinaemia syndrome).[1]


Hypoprothrombinemia can be treated with periodic infusions of purified prothrombin complexes.[2]


  1. Bajaj S, Rapaport S, Fierer D, Herbst K, Schwartz D (1983). "A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome". Blood. 61 (4): 684–92. PMID 6403077.
  2. Lechler E (1999). "Use of prothrombin complex concentrates for prophylaxis and treatment of bleeding episodes in patients with hereditary deficiency of prothrombin, factor VII, factor X, protein C protein S, or protein Z.". Thromb Res. 95 (4 Suppl 1): S39–50. doi:10.1016/S0049-3848(99)00083-3. PMID 10499908.

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