Hypoglycemia risk factors

Jump to navigation Jump to search

Hypoglycemia Microchapters


Patient Information


Historical Perspective




Differentiating Hypoglycemia from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


Diagnostic criteria

History and Symptoms

Physical Examination

Laboratory Findings


Chest X Ray



Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Hypoglycemia risk factors On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Hypoglycemia risk factors

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hypoglycemia risk factors

CDC on Hypoglycemia risk factors

Hypoglycemia risk factors in the news

Blogs on Hypoglycemia risk factors

Directions to Hospitals Treating Hypoglycemia

Risk calculators and risk factors for Hypoglycemia risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]


Risk factors of hypoglycemia include diabetic patients with excessive insulin doses especially after missed meals or after exercise. Nocturnal fasting and alcohol intake are less common risk factors in diabetic patients.

Risk Factors

Risk factors of hypoglycemia include:[1][2]

Risk factors for hypoglycemia-associated autonomic failure

There are three defense mechanisms against hypoglycemia:[3][4]

Failure of any of these defense mechanisms increase the chance of hypoglycemia. This occurs rapidly in type 1 diabetes and more gradually in type 2 diabetes mainly due to:[5]

  • Absolute endogenous insulin deficiency in type1 DM
  • A history of severe hypoglycemia, hypoglycemia unawareness, or both
  • Aggressive glycemic therapy (lower HbA1C levels, lower glycemic goals)


  1. Cryer PE, Axelrod L, Grossman AB, Heller SR, Montori VM, Seaquist ER; et al. (2009). "Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline". J Clin Endocrinol Metab. 94 (3): 709–28. doi:10.1210/jc.2008-1410. PMID 19088155.
  2. Cryer PE, Davis SN, Shamoon H (2003). "Hypoglycemia in diabetes". Diabetes Care. 26 (6): 1902–12. PMID 12766131.
  3. Cryer PE (2002). "Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes". Diabetologia. 45 (7): 937–48. doi:10.1007/s00125-002-0822-9. PMID 12136392.
  4. Cryer PE (2004). "Diverse causes of hypoglycemia-associated autonomic failure in diabetes". N Engl J Med. 350 (22): 2272–9. doi:10.1056/NEJMra031354. PMID 15163777.
  5. Cryer PE (2008). "The barrier of hypoglycemia in diabetes". Diabetes. 57 (12): 3169–76. doi:10.2337/db08-1084. PMC 2584119. PMID 19033403.