Hypernatremia historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Feham Tariq, MD [2]


In 1858, Claude Bernard, French physiologist first proposed a direct relationship between the central nervous system and renal excretion of osmotically active solutes. In 1913, Jungmann and Meyer in Germany induced polyuria and increased urinary salt excretion in animals through medullary lesion. In 1950, Peters, Welt, and co-workers described few patients with encephalitis, hypertensive intracranial hemorrhage, and bulbar poliomyelitis who presented with severe dehydration and hypernatremia.

Historical Perspective

The historical perspective of hypernatremia is as follows:[1][2][3][4]


  • In 1952, Welt and colleagues presented patients with cerebral lesions (including trauma, tumor, and infection) and severe hypernatremia with clinical dehydration but no potassium retention.


  1. J. Barcroft & H. Straub (1910). "The secretion of urine". The Journal of physiology. 41 (3–4): 145–167. PMID 16993045. Unknown parameter |month= ignored (help)
  2. Czerny, A (1935). Ergebnisse der Inneren Medizin und Kinderheilkunde : Achtundvierzigster Band. Berlin, Heidelberg: Springer Berlin Heidelberg. ISBN 9783642906701.
  3. J. P. PETERS, L. G. WELT, E. A. H. SIMS, J. ORLOFF & J. NEEDHAM (1950). "A salt-wasting syndrome associated with cerebral disease". Transactions of the Association of American Physicians. 63: 57–64. PMID 14855556.
  4. L. G. WELT, D. W. SELDIN, W. P. NELSON, W. J. GERMAN & J. P. PETERS (1952). "Role of the central nervous system in metabolism of electrolytes and water". A.M.A. archives of internal medicine. 90 (3): 355–378. PMID 14952060. Unknown parameter |month= ignored (help)

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