Hodgkin's lymphoma history and symptoms
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The most common symptoms of classic Hodgkin lymphoma include painless localized peripheral lymphadenopathy, B symptoms (fever, night sweats, weight loss), and pruritus. Less common symptoms of Hodgkin lymphoma include cough, chest pain, breathing problems, pain or feeling of fullness below the ribs, pain in lymph nodes after drinking alcohol, skin blushing or flushing, bone pain, and leg swelling.
History and Symptoms
- Hodgkin lymphoma begins at a single site of the lymphatic system, generally a lymph node, and then progresses to adjacent lymph nodes through lymphatic vessels before spreading to other sites and organs. The majority of patients present with an asymptomatic lymphadenopathy most often a site above the diaphragm, or as an accidental mediastinal mass on chest x-ray.
- Occasionally patients may present with nonspecific symptoms and signs that are more compatible with infection than malignant disease.
- B symptoms or constitutional symptoms, include fever (>100.4°F), drenching night sweats, and unexplained weight loss (>10% of total body weight) may present up to 50 percent of patients with advanced disease.
- Pruritus may be present before the diagnosis of Hodgkin lymphoma by months or even a year or more.
- Painless lymphadenopathy with a rubbery consistency most often a site above the diaphragm,
- Systemic B symptoms:
- Mediastinal mass effects include:
- Chest pain
- Shortness of breath
Less common symptoms
- Less common symptoms of Hodgkin's lymphoma include the following:
- P. M. Mauch, L. A. Kalish, M. Kadin, C. N. Coleman, R. Osteen & S. Hellman (1993). "Patterns of presentation of Hodgkin disease. Implications for etiology and pathogenesis". Cancer. 71 (6): 2062–2071. PMID 8443755. Unknown parameter
- Stephen M. Ansell (2015). "Hodgkin Lymphoma: Diagnosis and Treatment". Mayo Clinic proceedings. 90 (11): 1574–1583. doi:10.1016/j.mayocp.2015.07.005. PMID 26541251. Unknown parameter
- P. G. Gobbi, C. Cavalli, A. Gendarini, A. Crema, G. Ricevuti, M. Federico, U. Di Prisco & E. Ascari (1985). "Reevaluation of prognostic significance of symptoms in Hodgkin's disease". Cancer. 56 (12): 2874–2880. PMID 4052959. Unknown parameter
- G. R. Good & M. J. DiNubile (1995). "Images in clinical medicine. Cyclic fever in Hodgkin's disease (Pel-Ebstein fever)". The New England journal of medicine. 332 (7): 436. doi:10.1056/NEJM199502163320705. PMID 7824016. Unknown parameter