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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



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Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.[1][2][3]


This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.[3]

See also


  1. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  2. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  3. 3.0 3.1 "Entrez Gene: HOXB5 homeobox B5".<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

Further reading

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  • Galang CK, Hauser CA (May 1992). "Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product". The New Biologist. 4 (5): 558–68. PMID 1355360.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (Oct 1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity. 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (Jun 1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity. 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (Dec 1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America. 83 (23): 9104–8. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Hart CP, Awgulewitsch A, Fainsod A, McGinnis W, Ruddle FH (Nov 1985). "Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus". Cell. 43 (1): 9–18. doi:10.1016/0092-8674(85)90007-8. PMID 3000607.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Xu WM, Gorman PA, Rider SH, Hedge PJ, Moore G, Prichard C, Sheer D, Solomon E (Nov 1988). "Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer". Proceedings of the National Academy of Sciences of the United States of America. 85 (22): 8563–7. doi:10.1073/pnas.85.22.8563. PMC 282499. PMID 3186746.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Simeone A, Mavilio F, Bottero L, Giampaolo A, Russo G, Faiella A, Boncinelli E, Peschle C (1986). "A human homoeo box gene specifically expressed in spinal cord during embryonic development". Nature. 320 (6064): 763–5. doi:10.1038/320763a0. PMID 3453105.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Hauser CA, Joyner AL, Klein RD, Learned TK, Martin GR, Tjian R (Nov 1985). "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos". Cell. 43 (1): 19–28. doi:10.1016/0092-8674(85)90008-X. PMID 4075393.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Levine M, Rubin GM, Tjian R (Oct 1984). "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila". Cell. 38 (3): 667–73. doi:10.1016/0092-8674(84)90261-7. PMID 6091895.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Galang CK, Hauser CA (Aug 1993). "Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro". Molecular and Cellular Biology. 13 (8): 4609–17. doi:10.1128/mcb.13.8.4609. PMC 360087. PMID 8101633.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Kuliev A, Kukharenko V, Morozov G, Freidine M, Rechitsky S, Verlinsky O, Ivakhnenko V, Gindilis V, Strom C, Verlinsky Y (Feb 1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". Journal of Assisted Reproduction and Genetics. 13 (2): 177–81. doi:10.1007/BF02072541. PMID 8688592.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Sakach M, Safaei R (Aug 1996). "Localization of the HoxB5 protein in the developing CNS of late gestational mouse embryos". International Journal of Developmental Neuroscience. 14 (5): 567–73. doi:10.1016/0736-5748(96)00052-4. PMID 8930688.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Archavachotikul K, Ciccone TJ, Chinoy MR, Nielsen HC, Volpe MV (Mar 2002). "Thyroid hormone affects embryonic mouse lung branching morphogenesis and cellular differentiation". American Journal of Physiology. Lung Cellular and Molecular Physiology. 282 (3): L359–69. doi:10.1152/ajplung.00400.2000. PMID 11839528.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.