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major histocompatibility complex (human), class I, B47
Alleles B*4701
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*4701
EBI-HLA B*4702
EBI-HLA B*4703
Locus chr.6 6p21.31

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HLA-B47 (B47) is an HLA-B serotype. The serotype identifies the HLA-B*47 gene products (B*4701, B*4702, B*4703) .[1] Comparison of B47 nucleotide sequence with other HLA-B sequences shows a segment of 228 bp identical with B44 in the alpha 1 domain and a segment of 218 bp identical with B27 in the alpha 2 domain, but only a 91 bp segment of identity with B13 in the alpha 1 domain. The complex pattern of substitutions and their degree of divergence indicate that HLA-B13 and HLA-Bw47 alleles are not related by a simple mutational event.[2] B47 is linked to (close to on the chromosome) a gene that causes adrenal deficiency. B47 is generally low in frequency and with highest known frequencies in Central and Western Africa. (For terminology help see: HLA-serotype tutorial)


B47 serotype recognition of Some HLA B*47 allele-group gene products[3]
B*47 B47 Other Sample
allele % % size (N)
4701 50 37 317
4702 40 40 5
4703 25 50 4

Serotyping for B47 is poor and typing is best performed with SSP-PCR or gene sequencing.

Disease Associations

B47 is linked to Adrenal 21-hydroxylase deficiency.[2] The CYP21 gene is located close to B47 between HLA-B and HLA-DRB1 locus.

B*4701 frequencies

HLA B*4701 frequencies
ref. Population (%)
[4] Bamileke (Cameroon) 2.6
[4] Zapotec (Oaxaca, Mexico) 2.2
[4] Niokholo Mandinka (Senegal) 1.6
[4] Mbenzele Pygmy (CAR) 1.5
[4] Nandi (Kenya) 1.3
[4] Sudanese 1.3
[4] Yaounde City (Cameroon) 1.1
[4] Lusaka (Zambia) 1.1
[4] Central Portugal 1.0
[4] Bulgaria 0.9
[4] Czech Republic 0.9
[4] Cape Verde Islands 0.8
[4] Berber (Morocco) 0.7
[4] Finland 0.6
[4] Svans (Georgia) 0.6
[4] Bergamo (Italy) 0.6
[4] Romanians 0.6
[4] North Delhi ((India)) 0.5
[4] Orkney Isles (Scotland) 0.5
[4] Basque (Guipuscoa, Spain) 0.5
[4] Southeastern (France) 0.4
[4] Oman 0.4
[4] Kenya 0.3
Regions of Africa with Higher B4701 frequencies
Orange = 1 to 3%
Yellow = 0.1 to 1%


  1. Marsh SG, Albert ED, Bodmer WF; et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
  2. 2.0 2.1 Zemmour J, Ennis PD, Parham P, Dupont B (1988). "Comparison of the structure of HLA-B47 to HLA-B13 and its relationship to 21-hydroxylase deficiency". Immunogenetics. 27 (4): 281–7. PMID 3257938.
  3. derived from IMGT/HLA
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 4.22 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in |title= (help)


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