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major histocompatibility complex (human), class I, B82
Alleles B*8201
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*8201
EBI-HLA B*8202
Locus chr.6 6p21.31

HLA-B*82 (B*82) is an HLA-B allele-group. There is no current useful serotyping for HLA-B*82 gene products.[1] B*8201 was first identified by sequence analysis and appears to be derived by gene conversion between B*5602 and another HLA class I allele.[2], later B*8202 was identified in a caucasian and was suggested to be ancestral to B*8201, as product between gene conversion of B*5602 allele and B*4501 allele. B*82 is more common in East Africa, Kenya and Sudan, the frequency of B*8201 is found in the peoples to the west, sporadically in Central and West Africa, B*8202 is found in Sudan and Saudi Arabia.[3]


B82 serotype recognition of Some HLA B*82 allele-group gene products[4]
B*82 B82 other Sample
allele % % size (N)
8201 3 79 146

Allele frequencies

HLA B*8201 frequencies
ref. Population (%)
[5] Luo (Kenya) 1.9
[5] Guinea Bissau 0.8
[5] Natal Zulu (S. Africa) 0.5
[5] Beti (Cameroon) 0.3
[5] Kenya 0.3
[5] Kampala (Uganda) 0.3
[5] Nandi (Kenya) 0.2
HLA B*8202 frequencies
[5] Sudanese 2.5
[5] Kenya 0.7
[5] Guraiat and Hail (Saudi Arabia) 0.2


  1. Marsh SG, Albert ED, Bodmer WF; et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
  2. Hurley CK, Steiner N, Hoyer RJ; et al. (1996). "Novel HLA-B alleles, B*8201, B*3515 and B*5106, add to the complexity of serologic identification of HLA types". Tissue Antigens. 47 (3): 179–87. PMID 8740766.
  3. Cox ST, Hossain E, McWhinnie A, Prokupek B, Madrigal JA, Little AM (2000). "HLA-B*8202 identified in a Caucasoid potential bone marrow donor". Tissue Antigens. 56 (2): 188–91. PMID 11019925.
  4. derived from IMGT/HLA
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in |title= (help)


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