Ganglionic blocker

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


A ganglionic blocker is a type of medication which inhibits postganglionic transmission, primariliy by acting as a nicotinic antagonist, for example hexamethonium, pentolinium, mecamylamine, trimetaphan and pempidine.

Ganglionic blockers are used less frequently now than they were in the past, because more selective agents are now available. However, they are still used in some emergency situations, such as aortic dissection.

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