FOXH1

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VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.[1][2]

Function

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[2]

Interactions

FOXH1 has been shown to interact with DRAP1[3] and Mothers against decapentaplegic homolog 2.[4][5][6][7][8]

See also

References

  1. Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B (August 1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer". Mol Cell. 2 (1): 121–7. doi:10.1016/S1097-2765(00)80120-3. PMID 9702198.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  2. 2.0 2.1 "Entrez Gene: FOXH1 forkhead box H1".<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  3. Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM (December 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  4. Wotton D, Lo RS, Lee S, Massagué J (April 1999). "A Smad transcriptional corepressor". Cell. 97 (1): 29–39. doi:10.1016/S0092-8674(00)80712-6. PMID 10199400.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  5. Liu B, Dou CL, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. 19 (1): 424–30. PMC 83900. PMID 9858566.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  6. Liu F, Pouponnot C, Massagué J (December 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. PMC 316747. PMID 9389648.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  7. Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (September 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  8. Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (September 1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature. 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.