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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Cryptobiosis is an ametabolic state of life entered by some lower organisms in response to adverse environmental conditions such as desiccation, freezing, and oxygen deficiency. In the cryptobiotic state, all metabolic procedures stop, preventing reproduction, development, and repair. An organism in a cryptobiotic state can essentially live indefinitely until environmental conditions return to being hospitable. When this occurs, the organism will return to its metabolic state of life as it was prior to the cryptobiosis.

Forms of cryptobiosis

There are several forms of cryptobiosis. These are outlined below.


Anhydrobiosis is the most studied form of cryptobiosis and occurs in situations of extreme desiccation. The term anhydrobiosis derives from the Greek for "life without water" and is most commonly used for the desiccation tolerance observed in certain invertebrate animals such as bdelloid rotifers, tardigrades, brine shrimp and nematodes. However, other life forms, including the resurrection plant Craterostigma plantagineum, the majority of plant seeds, and many micro-organisms such as bakers' yeast, also exhibit desiccation tolerance. Invertebrates undergoing anhydrobiosis often contract into a smaller shape and some proceed to form a sugar called trehalose. Desiccation tolerance in plants is associated with the production of another sugar, sucrose. These sugars are thought to protect the organism from desiccation damage, and studies have shown that anhydrobiotic organisms can survive for decades in the dry state. In some creatures, such as bdelloid rotifers, no trehalose has been found, which has led scientists to propose other mechanisms of anhydrobiosis.

As of 2004, a new application of anhydrobiosis is being applied to vaccines. The process allows some organisms to survive dried-up by replacing water with a sugar solution that keeps cells in a state of suspended animation until rehydration occurs. In vaccines, the process can produce a dry vaccine that reactivates once it is injected into the body. In theory, dry-vaccine technology could be used on any vaccine, including live vaccines such as the one for measles. It could also potentially be adapted to allow a vaccine's slow release, eliminating the need for boosters. This proposes to eliminate the need for refrigerating vaccines, thus making dry vaccines more widely available throughout the developing world where refrigeration, electricity, and proper storage are less accessible.(source BBC News: [2] )


Anoxybiosis isn't considered a form of cryptobiosis by some. It takes place in situations lacking oxygen, and involves the organism intaking water and becoming turgid and immobile. Studies of the survival rates of organisms during anoxybiosis have given conflicting results.


The cryptobiotic response to high levels of environmental toxins.


Cryobiosis is a form of cryptobiosis that takes place in reaction to decreased temperature. To initiate cryobiosis, the organism freezes all of the water within its cells. This allows the organism to endure the freezing temperatures until more hospitable conditions return. Studies have shown that the longer an organism remains in cryobiosis, the longer it takes for the organism to come out of cryobiosis. This is because the organism must use its own energy to come out of cryobiosis, and the longer it stays in cryobiosis the less energy it has.


Osmobiosis is the least studied of the four types of cryptobiosis. Osmobiosis occurs in response to increased solute concentration in the solution the organism lives in. Not much is known for sure, other than that osmobiosis appears to involve a cessation of metabolism.


The most commonly-known organism that undergoes cryptobiosis is Artemia salina, commonly known for their brand name Sea-monkeys. The tardigrade, or water bear, is the most studied and most notable, partially because it can undergo all five types of cryptobiosis. While in this state, its metabolism lowers to less than 0.01% of what is normal, and its water content can drop to 1% of normal. It can withstand extreme temperature, radiation, and pressure while in a cryptobiotic state.

Some Nematodes and Rotifers can also undergo cryptobiosis.

See also

External links

Further reading

  • David A. Wharton, Life at the Limits: Organisms in Extreme Environments, Cambridge University Press, 2002, hardcover, ISBN 0-521-78212-0
  • D. Bartels and F. Salamini, Desiccation Tolerance in the Resurrection Plant Craterostigma plantagineum. A Contribution to the Study of Drought Tolerance at the Molecular Level, Plant Physiol, December 2001, Vol. 127, pp. 1346-1353 [3]

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