Cryoglobulinemia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Feham Tariq, MD [2]


Common causes of cryoglobulinemia are primarily hematologic, oncologic, and rheumatic. Less commonly, cryoglobulinemia can be caused by infections such as HIV or Hepatitis C.


Common Causes

The common causes of cryoglobulinemia are as follows:[1][2][3][4]

Causes by Organ System

Cardiovascular Hypersensitivity vasculitis, Raynaud's phenomenon
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic Purpura
Drug Side Effect No underlying causes
Ear Nose Throat Sjögren's syndrome
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic Sjögren's syndrome
Hematologic B-cell hyperactivation  , B-cell hyperproliferation, Leukemia, Multiple myeloma, Myeloma, Primary macroglobulinemia, Purpura, Raynaud's phenomenon
Iatrogenic No underlying causes
Infectious Disease Hepatitis c, Hiv, Mycoplasma pneumonia
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Leukemia, Multiple myeloma, Myeloma, Primary macroglobulinemia, Waldenström macroglobulinaemia
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Mycoplasma pneumonia
Renal/Electrolyte Glomerulonephritis
Rheumatology/Immunology/Allergy Arthropathy, Rheumatoid arthritis, Rheumatoid disease, Systemic lupus erythematosus
Sexual Hiv
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order


  1. Scotto G, Cibelli DC, Saracino A, Prato R, Palumbo E, Fazio V; et al. (2006). "Cryoglobulinemia in subjects with HCV infection alone, HIV infection and HCV/HIV coinfection". J Infect. 52 (4): 294–9. doi:10.1016/j.jinf.2005.05.025. PMID 16026843.
  2. Suszek D, Majdan M (2018). "[Cryoglobulins and cryoglobulinemic vasculitis]". Wiad Lek. 71 (1 pt 1): 59–63. PMID 29558353.
  3. Blank N, Lorenz HM (2016). "[Cryoglobulinemic vasculitis]". Z Rheumatol. 75 (3): 303–15. doi:10.1007/s00393-016-0076-4. PMID 27034078.
  4. Ramos-Casals M, Trejo O, García-Carrasco M, Cervera R, Font J (2000). "Mixed cryoglobulinemia: new concepts". Lupus. 9 (2): 83–91. doi:10.1191/096120300678828127. PMID 10787003.

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