Chronic renal failure primary prevention
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Effective measures for the primary prevention of chronic renal failure include:
- Treatment of reversible exacerbants
- Volume Depletion
- Nonoliguric ARF typically occurs at 7-10 days
- Increased risk with older patients, prolonged therapy and greater total dose
- IV contrast
- ARF usually occurs within 24-48 hours of dye administration
- Peak Cr after 5-7 days with return to baseline at 10-14 days
- Risk ARF increased with DM and higher volume of dye
- Note: certain meds increase serum Cr (via inhibiting Cr secretion or interfering with assay) without changing GFR, e.g. cimetidine, trimethoprim (TMP), cefoxitin, flucytosine; BUN will not rise because GFR is preserved
- Urinary tract obstruction
- Most commonly due to prostatic hypertrophy in men
- Other causes:
- Zandi-Nejad K, Brenner BM (October 2005). "Primary and secondary prevention of chronic kidney disease". J. Hypertens. 23 (10): 1771–6. PMID 16148593.
- Ogborne A, Collier D (1979). "A rehabilitation programme with a controlled drinking option". Int J Soc Psychiatry. 25 (1): 47–55. doi:10.1177/002076407902500107. PMID 89104.
- Roth KS, Koo HP, Spottswood SE, Chan JC (June 2002). "Obstructive uropathy: an important cause of chronic renal failure in children". Clin Pediatr (Phila). 41 (5): 309–14. doi:10.1177/000992280204100503. PMID 12086196.
- Sung BM, Oh DJ, Choi MH, Choi HM (March 2018). "Chronic kidney disease in neurogenic bladder". Nephrology (Carlton). 23 (3): 231–236. doi:10.1111/nep.12990. PMID 28035730.