CURE bleeding criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

CURE Clinical Trials:

The Clopidogrel In Unstable Angina To Prevent Recurrent Events Trial

Clopidogrel In Unstable Angina To Prevent Recurrent Ischemic Events[1]

  • Major Bleeding

Life-threatening (fatal, intracranial, requiring surgical intervention, results in substantial hypotension requiring the use of intravenous inotropic agents) Hemoglobin decrease ≥5 g/dL or required ≥4 U of blood Other major bleeding Transfusion of 2–3 U, intraocular

  • Minor

Led to discontinuation of study drug


  1. Eikelboom JW, Mehta SR, Anand SS, Xie C, Fox KA, Yusuf S (2006). "Adverse impact of bleeding on prognosis in patients with acute coronary syndromes". Circulation. 114 (8): 774–82. doi:10.1161/CIRCULATIONAHA.106.612812. PMID 16908769.

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