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Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.[1][2][3]

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.[3]


CDKN3 has been shown to interact with Cyclin-dependent kinase 2,[4][5][6] Cdk1[1][5] and MS4A3.[7]


  1. 1.0 1.1 Gyuris J, Golemis E, Chertkov H, Brent R (Dec 1993). "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2". Cell. 75 (4): 791–803. doi:10.1016/0092-8674(93)90498-F. PMID 8242750.
  2. Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (May 1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID 7698009.
  3. 3.0 3.1 "Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)".
  4. Yeh, Chau-Ting; Lu Su-Chuan; Chao Chung-Hao; Chao Mei-Ling (May 2003). "Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant". Biochem. Biophys. Res. Commun. United States. 305 (2): 311–4. doi:10.1016/S0006-291X(03)00757-5. ISSN 0006-291X. PMID 12745075.
  5. 5.0 5.1 Hannon, G J; Casso D; Beach D (Mar 1994). "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 91 (5): 1731–5. Bibcode:1994PNAS...91.1731H. doi:10.1073/pnas.91.5.1731. ISSN 0027-8424. PMC 43237. PMID 8127873.
  6. Harper, J W; Adami G R; Wei N; Keyomarsi K; Elledge S J (Nov 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. UNITED STATES. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. ISSN 0092-8674. PMID 8242751.
  7. Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. United States. 109 (1): 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350.

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