Jump to navigation Jump to search
Monoclonal antibody
TypeWhole antibody
SourceTemplate:Infobox drug/mab source
TargetIL-12 and IL-23
Clinical data
ATC code
Legal status
Legal status
  • investigational
Pharmacokinetic data
CAS Number
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Molar mass146.5 kDa
 ☒N☑Y (what is this?)  (verify)

WikiDoc Resources for Briakinumab


Most recent articles on Briakinumab

Most cited articles on Briakinumab

Review articles on Briakinumab

Articles on Briakinumab in N Eng J Med, Lancet, BMJ


Powerpoint slides on Briakinumab

Images of Briakinumab

Photos of Briakinumab

Podcasts & MP3s on Briakinumab

Videos on Briakinumab

Evidence Based Medicine

Cochrane Collaboration on Briakinumab

Bandolier on Briakinumab

TRIP on Briakinumab

Clinical Trials

Ongoing Trials on Briakinumab at Clinical

Trial results on Briakinumab

Clinical Trials on Briakinumab at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Briakinumab

NICE Guidance on Briakinumab


FDA on Briakinumab

CDC on Briakinumab


Books on Briakinumab


Briakinumab in the news

Be alerted to news on Briakinumab

News trends on Briakinumab


Blogs on Briakinumab


Definitions of Briakinumab

Patient Resources / Community

Patient resources on Briakinumab

Discussion groups on Briakinumab

Patient Handouts on Briakinumab

Directions to Hospitals Treating Briakinumab

Risk calculators and risk factors for Briakinumab

Healthcare Provider Resources

Symptoms of Briakinumab

Causes & Risk Factors for Briakinumab

Diagnostic studies for Briakinumab

Treatment of Briakinumab

Continuing Medical Education (CME)

CME Programs on Briakinumab


Briakinumab en Espanol

Briakinumab en Francais


Briakinumab in the Marketplace

Patents on Briakinumab

Experimental / Informatics

List of terms related to Briakinumab

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Briakinumab (ABT-874) is a human monoclonal antibody being developed by Abbott Laboratories for the treatment of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. As of 2011 drug development for psoriasis has been discontinued in the U.S. and Europe.[1]

Like ustekinumab, the antibody targets the interleukins 12 and 23.[2]


The candidate drug was discovered by Cambridge Antibody Technology in collaboration with Abbott.[3][4]


As of November 2009, Phase III clinical trials for plaque psoriasis[5][6] and a Phase II trial for multiple sclerosis[7] have been completed, and a Phase II trial for Crohn's disease is underway.[8]

Briakinumab was compared to etanercept and placebo in several double-blind trials. The Psoriasis Area Severity Index (PASI) was reduced significantly better than under the comparator treatments. 81–82% of patients under briakinumab, 40–56% under etanercept, and 7% under placebo reached PASI reduction of at least 75%.[9] No head-to-head studies against ustekinumab, the other IL-12/23 inhibitor, are available.

On January 15, 2011, Abbott announced the withdrawal of its application to the US FDA and European regulators for briakinumab. Following feedback from regulatory authorities indicating the need for further analysis, including the potential for additional studies, Abbott withdrew its applications and was evaluating next steps including possible resubmission at a later date. This compound has never been resubmitted for approval.


This is the second candidate from a deal with Cambridge Antibody Technology that Abbott have taken to late-stage clinical trials. As a result of the protracted royalty dispute over Humira Abbott agreed to pay CAT a reduced royalty of 4.75% on any future sales of ABT-874, from which CAT will pay a portion to the MRC and other licensors (according to CAT's 1997 agreement with the MRC).[10]


  1. "Abbott withdraws briakinumab applications in USA, Europe". PharmaTimes. 17 January 2011.
  2. PMID 19569977 (PMID 19569977)
    Citation will be completed automatically in a few minutes. Jump the queue or expand by hand
  3. "Abbott 2007 Annual Report: Pharmaceuticals". Retrieved 2010-05-12.
  4. MedImmune: External R&D Partnering
  5. Clinical trial number NCT00570986 for "A Study Comparing the Safety and Efficacy of Two Dosing Regimens of ABT-874 to Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis" at
  6. Clinical trial number NCT00691964 for "Study Comparing the Efficacy and Safety of ABT-874 to Etanercept and Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis" at
  7. Clinical trial number NCT00086671 for "Safety and Effectiveness of Two Doses of ABT-874 as Compared to Placebo in Subjects With Multiple Sclerosis (MS)" at
  8. Clinical trial number NCT00562887 for "Dose Ranging Study Comparing the Efficacy, Safety and Pharmacokinetics of Intravenous Infusions of ABT-874 vs Placebo in Subjects With Active Crohn's Disease" at
  9. Abbott Press Release: Abbott Reports Psoriasis Phase III Results of its Investigational IL-12/23 Inhibitor Briakinumab (ABT-874)
  10. The Free Library: Cambridge Antibody Technology and Abbott Agree Regarding Royalties