Beriberi other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdelrahman Ibrahim Abushouk, MD[2]


There are no other diagnostic studies associated with Beriberi.

Nerve conduction and electromyography

Nerve conduction study and electromyography may help.

Thiamine deficiency has been reported to display demyelination[1][2][3] although per Shible, citing the two Koike reports, this may be late stage finding[4] and due to severe protein calorie malnutrition[5].

After bariatric surgery, 6% of patients developed polyneuropathy (none showed demyelination although inflammation was present) [6]. However, both axonal and demyelination have been reported[7].

However, demyelination after bariatric surgery may be associated with:

Interpretation of nerve conduction studies is difficult and demyelination can be secondary to severe axonal degeneration[11].


  1. Hamel J, Logigian EL (2018). "Acute nutritional axonal neuropathy". Muscle Nerve. 57 (1): 33–39. doi:10.1002/mus.25702. PMID 28556429.
  2. Koike H, Ito S, Morozumi S, Kawagashira Y, Iijima M, Hattori N; et al. (2008). "Rapidly developing weakness mimicking Guillain-Barré syndrome in beriberi neuropathy: two case reports". Nutrition. 24 (7–8): 776–80. doi:10.1016/j.nut.2008.02.022. PMID 18440777.
  3. Koike H, Misu K, Hattori N, Ito S, Ichimura M, Ito H; et al. (2001). "Postgastrectomy polyneuropathy with thiamine deficiency". J Neurol Neurosurg Psychiatry. 71 (3): 357–62. doi:10.1136/jnnp.71.3.357. PMC 1737557. PMID 11511711.
  4. Shible AA, Ramadurai D, Gergen D, Reynolds PM (2019). "Dry Beriberi Due to Thiamine Deficiency Associated with Peripheral Neuropathy and Wernicke's Encephalopathy Mimicking Guillain-Barré syndrome: A Case Report and Review of the Literature". Am J Case Rep. 20: 330–334. doi:10.12659/AJCR.914051. PMC 6429982. PMID 30862772.
  5. Chopra JS, Dhand UK, Mehta S, Bakshi V, Rana S, Mehta J (1986). "Effect of proteincalorie malnutrition on peripheral nerves. A clinical, electrophysiological and histopathological study". Brain. 109 ( Pt 2): 307–23. doi:10.1093/brain/109.2.307. PMID 3082465.
  6. Thaisetthawatkul P, Collazo-Clavell ML, Sarr MG, Norell JE, Dyck PJ (2004). "A controlled study of peripheral neuropathy after bariatric surgery". Neurology. 63 (8): 1462–70. doi:10.1212/01.wnl.0000142038.43946.06. PMID 15505166.
  7. Philippi N, Vinzio S, Collongues N, Vix M, Boehm N, Tranchant C; et al. (2011). "[Peripheral neuropathies after bariatric surgery]". Rev Neurol (Paris). 167 (8–9): 607–14. doi:10.1016/j.neurol.2011.01.011. PMID 21514611.
  8. Amin A, Khoury NC, Lacayo M, Kostanyan S (2022). "Copper Deficiency-Induced Neuropathy After Bariatric Surgery Disguised as Demyelinating Disease: A Case Report". Cureus. 14 (2): e22705. doi:10.7759/cureus.22705. PMC 8967068 Check |pmc= value (help). PMID 35386142 Check |pmid= value (help).
  9. Landais AF (2014). "Rare neurologic complication of bariatric surgery: acute motor axonal neuropathy (AMAN), a severe motor axonal form of the Guillain Barré syndrome". Surg Obes Relat Dis. 10 (6): e85–7. doi:10.1016/j.soard.2014.02.019. PMID 24913591.
  10. Ishaque N, Khealani BA, Shariff AH, Wasay M (2015). "Guillain-Barré syndrome (demyelinating) six weeks after bariatric surgery: A case report and literature review". Obes Res Clin Pract. 9 (4): 416–9. doi:10.1016/j.orcp.2015.02.001. PMID 25765350.. The report stated "fully compliant with the recommended diet plan and vitamin supplements" although these levels were not reported for confirmation.
  11. Van den Bergh PY, Piéret F (2004). "Electrodiagnostic criteria for acute and chronic inflammatory demyelinating polyradiculoneuropathy". Muscle Nerve. 29 (4): 565–74. doi:10.1002/mus.20022. PMID 15052622.

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