Jump to navigation Jump to search

WikiDoc Resources for Arcobacter


Most recent articles on Arcobacter

Most cited articles on Arcobacter

Review articles on Arcobacter

Articles on Arcobacter in N Eng J Med, Lancet, BMJ


Powerpoint slides on Arcobacter

Images of Arcobacter

Photos of Arcobacter

Podcasts & MP3s on Arcobacter

Videos on Arcobacter

Evidence Based Medicine

Cochrane Collaboration on Arcobacter

Bandolier on Arcobacter

TRIP on Arcobacter

Clinical Trials

Ongoing Trials on Arcobacter at Clinical

Trial results on Arcobacter

Clinical Trials on Arcobacter at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Arcobacter

NICE Guidance on Arcobacter


FDA on Arcobacter

CDC on Arcobacter


Books on Arcobacter


Arcobacter in the news

Be alerted to news on Arcobacter

News trends on Arcobacter


Blogs on Arcobacter


Definitions of Arcobacter

Patient Resources / Community

Patient resources on Arcobacter

Discussion groups on Arcobacter

Patient Handouts on Arcobacter

Directions to Hospitals Treating Arcobacter

Risk calculators and risk factors for Arcobacter

Healthcare Provider Resources

Symptoms of Arcobacter

Causes & Risk Factors for Arcobacter

Diagnostic studies for Arcobacter

Treatment of Arcobacter

Continuing Medical Education (CME)

CME Programs on Arcobacter


Arcobacter en Espanol

Arcobacter en Francais


Arcobacter in the Marketplace

Patents on Arcobacter

Experimental / Informatics

List of terms related to Arcobacter

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Arcobacter is a genus of Gram-negative, spiral-shaped bacteria in the epsilonproteobacteria class.[1] It shows an unusually wide range of habitats, and some species can be human and animal pathogens.[1][2] Species of the genus Arcobacter are found in both animal and environmental sources, making it unique among the epsilonproteobacteria.[3] This genus currently consists of five species: A. butzleri, A. cryaerophilus, A. skirrowii, A. nitrofigilis, and A. sulfidicus, although several other potential novel species have recently been described from varying environments.[3][4] Three of these five known species are pathogenic.[4] Members of this genus were first isolated in 1977 from aborted bovine fetuses. They are aerotolerant Campylobacter-like organisms, previously classified as Campylobacter.[5] The Arcobacter genus, in fact, was created as recently as 1992.[6] Although they are similar to this other genus, Arcobacter species can grow at lower temperatures than Campylobacter as well as in the air, which Campylobacter cannot.[5]

The name Arcobacter is derived from the Latin "arcus" meaning "bow" and the Greek "bacter" meaning "rod", and should be understood to mean "bow-shaped rod" or "curved rod". This is a reference to the characteristic curved shaped that most Arcobacter cells possess.[7]


Arcobacter species have been discovered as both animal and human pathogens within the past decade, thanks to improvements in isolation techniques.[5] Up to now, little is known about the mechanisms of pathogenicity or potential virulence factors of Arcobacter spp.[8] Since no routine diagnostic of these bacteria has been performed, the global prevalence of Arcobacter infection is rather underestimated and the exact routes of transmission are unknown.[9] There is evidence that livestock animals may be a significant reservoir of Arcobacter, and over the last few years, the presence of these organisms in raw meat products as well as in surface and ground water has received increasing attention.[8] In humans, A. butzleri and, less commonly, A. cryaerophilus have been linked to enteritis and occasionally bacteremia.[5] Symptoms of A. butzleri infections include diarrhea associated with abdominal pain, nausea, and vomiting or fever.[5] Studies of patients infected with A. butzleri have demonstrated that without treatment, symptoms endured for a very variable amount of time, from two days to several weeks.[6] When antimicrobial therapies were administered, the infection was eradicated within a few days, and all strains in the study were found to be susceptible to the antibiotics given.[6] A third species, A. skirrowii, has also recently been isolated from a patient with chronic diarrhea.[5] Although the microbiological and clinical features of Arcobacter are not yet well defined, initial studies of A. butzleri suggest that these bacteria display similar microbiological and clinical features as C. jejuni, but are more associated with a persistent, watery diarrhea than with the bloody diarrhea associated with C. jejuni.[5] Recent studies suggest that A. butzleri induces epithelial barrier dysfunction by changes in tight junction proteins and induction of epithelial apoptosis.[9] Based on this model, the virulence of A. butzleri seems to have two phases. An initial effect on tight junctions was observed first, followed by a late effect on cytotoxicity because of necrosis and induction of apoptosis.[9]

Nonpathogenic strains

A. nitrofigilis is a nitrogen-fixing bacterium isolated from the roots of the salt marsh plant Spartina alterniflora.[4] A. sulfidicus is an obligate microaerophile that oxidizes sulfides and is an autotrophic producer of filamentous sulfur.[4] Large populations of this bacterium produce mats of this solid, white sulfur filament.[10] These mats are useful in anchoring the bacteria to rocky surfaces in the face of flowing subsurface hydrothermal fluids, as well as providing important carpeting around hydrothermal vents that attracts other animals to that site and encourages them to settle and grow.[10] One interesting potential novel Arcobacter species, designated LA31BT, was isolated from water collected from a hypersaline lagoon.[3] Preliminary characterization based on 16S rRNA gene sequence analysis showed that LA31BT shared 94% identity with A. nitrofigilis, the type species of the genus, and taxonomic studies confirmed the phylogenetic affiliation of strain LA31BT to the genus Arcobacter.[3] Other analytical methods, however, showed that LA31BT was distinct from all recognized Arcobacter species. Most notably and of interest, LA31BT was found to be an obligate halophile, a trait not found among recognized Arcobacter species.[3]

Another unusual Arcobacter species, designated strain CAB, was isolated from marine sediment and found to have the capacity to grow via perchlorate reduction, the only member of the epsilonproteobacteria in pure culture to possess this rare metabolism.[11] Unlike most Arcobacter species, CAB was found to degrade carbohydrates, including fructose and catechol, and its cells often lacked the distinctive curvature typical of the Arcobacter genus.[11]


  1. 1.0 1.1 Madigan T, et al (2009) Brock Biology of Microorganisms, 12th edition. San Francisco: Pearson Education
  2. Miller, W. G.; Parker, C. T.; Rubenfield, M.; Mendz, G. L.; Wösten, M. M. S. M.; Ussery, D. W.; Stolz, J. F.; Binnewies, T. T.; Hallin, P. F.; Wang, G.; Malek, J. A.; Rogosin, A.; Stanker, L. H.; Mandrell, R. E. (2007). Fairhead, Cecile, ed. "The Complete Genome Sequence and Analysis of the Epsilonproteobacterium Arcobacter butzleri". PLoS ONE. 2 (12): e1358. Bibcode:2007PLoSO...2.1358M. doi:10.1371/journal.pone.0001358. PMC 2147049. PMID 18159241. open access publication – free to read
  3. 3.0 3.1 3.2 3.3 3.4 Donachie, Stuart. "Arcobacter halophilus sp. nov., the first obligate halophile in the genus Arcobacter".
  4. 4.0 4.1 4.2 4.3 Fera, M.T. "Detection of Arcobacter spp. in the Coastal Environment of the Mediterranean Sea".
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6
  6. 6.0 6.1 6.2 Prouzet-Mauleon, Valerie. "Arcobacter butzleri: Underestimated Enteropathogen".
  7. P. Vandamme, E. Falsen, R. Rossau, B. Hoste, P. Segers, R. Tytgat, and J. De Ley (Jan 1991). "Revision of Campylobacter, Helicobacter, and Wolinella Taxonomy: Emendation of Generic Descriptions and Proposal of Arcobacter gen. nov". International Journal of Systematic Bacteriology. 41 (1): 88–103. doi:10.1099/00207713-41-1-88. PMID 1704793.
  8. 8.0 8.1 "Relevant aspects of Arcobacter spp. as potential foodborne pathogen". Int. J. Food Microbiol. 102 (2): 127–35. July 2005. doi:10.1016/j.ijfoodmicro.2005.03.003. PMID 15982771.
  9. 9.0 9.1 9.2 Bucker, Roland. "Arcobacter butzleri Induces Barrier Dysfunction in Intestinal HT-29/B6 Cells".
  10. 10.0 10.1 Wirsen, Carl. "Is Life Thriving Deep Beneath the Seafloor?". Woods Hole Oceanographic Institution.
  11. 11.0 11.1 Carlström, Charlotte I.; Wang, Ouwei; Melnyk, Ryan A.; Bauer, Stefan; Lee, Joyce; Engelbrektson, Anna; Coates, John D. (2013). "Physiological and genetic description of dissimilatory perchlorate reduction by the novel marine bacterium Arcobacter sp. strain CAB". MBio. 4 (3): e00217-13. doi:10.1128/mBio.00217-13.