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Amygdalohippocampectomy is a surgical procedure for the treatment of epilepsy. It consists of the removal of the hippocampus, which has a role in memory, spatial awareness, and navigation,[1] and the amygdalae, which have a role in the processing and memory of emotional reactions,[2] both structures forming part of the limbic system of the brain.

Amygdalohippocampectomy is used only when all other treatment options have failed to resolve the epilepsy. It is an effective treatment for most patients. However, possible adverse side effects include impaired memory and defects in visual perception.


The procedure is indicated when the focal point of the seizures can be anatomically localized to the hippocampus and amygdala. Normally, to be considered for this procedure, one must have failed all first-line treatments.[3] The selective amygdalohippocampectomy will remove only the offending portions of the hippocampus and amygdala.[4] When data from studies of the electrophysiology and neuropathy vis-à-vis temporal lobe epilepsy determines this area to be the origin of seizure activity, the removal of the hippocampus and amygdala is usually indicated. Computer imaging is sometimes used to guide this procedure.[2] Patients continue normal activity after approximately six to eight weeks.

Statistics and side effects

Of 376 patients who had the amygdalohippocampectomy procedure performed, compared to other types of temporal lobe resections, two thirds of this population were reported free of disabling seizures.[5] Some patients report defects in visual perception[6] and impaired memory function. [7]


  1. Ekstrom, AD (2003). "Cellular networks underlying human spatial navigation" (PDF). Nature. 425 (6954): 184–188. PMID 12968182. Retrieved 2007-02-11. Unknown parameter |coauthors= ignored (help)<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  2. 2.0 2.1 Olivier A (2000). "Transcortical selective amygdalohippocampectomy in temporal lobe epilepsy". Can J Neurol Sci. 27 Suppl 1: S68–76, discussion S92–6. PMID 10830331.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  3. Smith KA, Detwiler PW, Porter RW (1999). "Surgical Treatment of Intractable Epilepsy". BNI Quarterly. 15 (1).<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  4. Bate H, Eldridge P, Varma T, Wieshmann UC (2007). "The seizure outcome after amygdalohippocampectomy and temporal lobectomy". Eur. J. Neurol. 14 (1): 90–4. doi:10.1111/j.1468-1331.2006.01565.x. PMID 17222120. Unknown parameter |month= ignored (help)<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  5. Engel J, Wiebe S, French J; et al. (2003). "Practice parameter: Temporal lobe and localized neocortical resections for epilepsy". Neurology. 60 (4): 538–47. PMID 12601090.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  6. Dr Novak Klaus (2005). "Visual Field Defects After Selective Transsylvian Amygdalohippocampectomy" (PDF). 14th Meeting of the World Society for Stereotactic and Functional Neurosurgery. Unknown parameter |coauthors= ignored (help)<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  7. Gleissner U, Helmstaedter C, Schramm J, Elger CE (2002). "Memory outcome after selective amygdalohippocampectomy: a study in 140 patients with temporal lobe epilepsy". Epilepsia. 43 (1): 87–95. doi:10.1046/j.1528-1157.2002.24101.x. PMID 11879392.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>