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Synonyms / Brand Names: Amlodipine Benzenesulfonate, Amlodipine Besilate, Amlodipine Free Base, Amlodipino, Amlodipinum,Amlocard, Amlodis, Amvaz, Coroval, Lipinox, Lotrel, benazepril, Benazepril HCl, Benazepril Hydrochloride, Benazeprilum, Briem, Cibacen, Cibacene

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Dosing and Administration

Treatment of hypertension
Amlodipine is an effective treatment of hypertension in once-daily doses of 2.5-10 mg while benazepril is effective in doses of 10-80 mg. In clinical trials of amlodipine/benazepril combination therapy using amlodipine doses of 2.5-10 mg and benazepril doses of 10-20 mg, the antihypertensive effects increased with increasing dose of amlodipine in all patient groups, and the effects increased with increasing dose of benazepril in nonblack groups. All patient groups benefited from the reduction in amlodipine-induced edema

Dose Titration Guided by Clinical Effect
A patient whose blood pressure is not adequately controlled with amlodipine (or another dihydropyridine) alone or with benazepril (or another ACE inhibitor) alone may be switched to combination therapy with Lotrel. The addition of benazepril to a regimen of amlodipine should not be expected to provide additional antihypertensive effect in African-Americans. However, all patient groups benefit from the reduction in amlodipine-induced edema. Dosage must be guided by clinical response; steady-state levels of benazepril and amlodipine will be reached after approximately 2 and 7 days of dosing, respectively.

FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.

Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.

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On line calculator of your patients weight in pounds to Kg for dosing estimates.

Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information

Trial Resources
Ongoing Trials, Trial Results

Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.

Media Resources
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Patient Resources
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International Resources
en Español

FDA Package Insert Resources



Side Effects

Drug Interactions



Instructions for Administration

How Supplied

Pharmacokinetics and Molecular Data

FDA label

FDA on Amlodipine/benazepril

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Publication Resources

Most Recent Articles on Amlodipine/benazepril

Review Articles on Amlodipine/benazepril

Articles on Amlodipine/benazepril in N Eng J Med, Lancet, BMJ

WikiDoc State of the Art Review

Textbook Information on Amlodipine/benazepril

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Trial Resources

Ongoing Trials with Amlodipine/benazepril at Clinical

Trial Results with Amlodipine/benazepril

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Guidelines & Evidence Based Medicine Resources

US National Guidelines Clearinghouse on Amlodipine/benazepril

Cochrane Collaboration on Amlodipine/benazepril

Cost Effectiveness of Amlodipine/benazepril

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Media Resources

Powerpoint Slides on Amlodipine/benazepril

Images of Amlodipine/benazepril

Podcasts & MP3s on Amlodipine/benazepril

Videos on Amlodipine/benazepril

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Patient Resources

Patient Resources on Amlodipine/benazepril

Discussion Groups on Amlodipine/benazepril

Patient Handouts on Amlodipine/benazepril

Blogs on Amlodipine/benazepril

Amlodipine/benazepril in the News

Amlodipine/benazepril in the Marketplace

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International Resources

Amlodipine/benazepril en Español

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Adapted from the FDA Package Insert.