Difference between revisions of "Transposition of the great vessels risk factors"

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{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com]; {{CZ}}; [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; '''Assistant Editor(s)-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu]
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{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com]; {{CZ}}; [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu] {{ADG}}
  
 
==Overview==
 
==Overview==
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TGA is not known to be associated with any specific single [[gene]] defect, but some studies have shown possible genetic association in some cases of TGA, involving deletions of [[22q11.2 deletion syndrome|chromosome 22q11]]. Other risk factors in the mother that may increase the risk of this condition include age over 40, [[alcoholism]], [[diabetes]], prenatal [[malnutrition]] and [[rubella]] or other viral illness during [[pregnancy]].
 +
 
==Risk factors==
 
==Risk factors==
*Generally, TGA is not known to be associated with any specific single gene defect, but some studies have shown possible genetic association in some cases of TGA, involving deletions of chromosome 22q11.  
+
Generally, TGA is not known to be associated with any specific single gene defect, but some studies have shown possible genetic association in some cases of TGA, involving deletions of [[Chromosome 22, microdeletion 22 q11|chromosome]] 22q11. Other risk factors in the mother that may increase the risk of this condition include:
Factors in the mother that may increase the risk of this condition include:
+
 
 
*Age over 40
 
*Age over 40
*Alcoholism
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*[[Alcoholism]]
*Diabetes
+
*[[Diabetes]]<ref name="pmid2404255">{{cite journal |vauthors=Becerra JE, Khoury MJ, Cordero JF, Erickson JD |title=Diabetes mellitus during pregnancy and the risks for specific birth defects: a population-based case-control study |journal=Pediatrics |volume=85 |issue=1 |pages=1–9 |date=January 1990 |pmid=2404255 |doi= |url=}}</ref>
*Prenatal nutrition
+
*Prenatal malnutrition
*Rubella or other viral illness during pregnancy
+
*[[Rubella]] or other viral illness during [[pregnancy]]<ref name="pmid11257060">{{cite journal |vauthors=Loffredo CA, Silbergeld EK, Ferencz C, Zhang J |title=Association of transposition of the great arteries in infants with maternal exposures to herbicides and rodenticides |journal=Am. J. Epidemiol. |volume=153 |issue=6 |pages=529–36 |date=March 2001 |pmid=11257060 |doi=10.1093/aje/153.6.529 |url=}}</ref>
 +
*Maternal use of anti eplileptic drugs<ref name="pmid16732768">{{cite journal |vauthors=Okuda H, Nagao T |title=Cardiovascular malformations induced by prenatal exposure to phenobarbital in rats |journal=Congenit Anom (Kyoto) |volume=46 |issue=2 |pages=97–104 |date=June 2006 |pmid=16732768 |doi=10.1111/j.1741-4520.2006.00109.x |url=}}</ref>
  
 
==References==
 
==References==

Latest revision as of 16:49, 19 February 2020

Transposition of the great vessels Microchapters

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Patient Information

Overview

Historical perspective

Classification

Dextro-transposition of the great arteries
L-transposition of the great arteries

Pathophysiology

Causes

Differentiating Transposition of the great vessels from other Diseases

Epidemiology and Demographics

Risk Factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]; Keri Shafer, M.D. [4]; Kristin Feeney, B.S. [5] Aditya Ganti M.B.B.S. [6]

Overview

TGA is not known to be associated with any specific single gene defect, but some studies have shown possible genetic association in some cases of TGA, involving deletions of chromosome 22q11. Other risk factors in the mother that may increase the risk of this condition include age over 40, alcoholism, diabetes, prenatal malnutrition and rubella or other viral illness during pregnancy.

Risk factors

Generally, TGA is not known to be associated with any specific single gene defect, but some studies have shown possible genetic association in some cases of TGA, involving deletions of chromosome 22q11. Other risk factors in the mother that may increase the risk of this condition include:

References

  1. Becerra JE, Khoury MJ, Cordero JF, Erickson JD (January 1990). "Diabetes mellitus during pregnancy and the risks for specific birth defects: a population-based case-control study". Pediatrics. 85 (1): 1–9. PMID 2404255.
  2. Loffredo CA, Silbergeld EK, Ferencz C, Zhang J (March 2001). "Association of transposition of the great arteries in infants with maternal exposures to herbicides and rodenticides". Am. J. Epidemiol. 153 (6): 529–36. doi:10.1093/aje/153.6.529. PMID 11257060.
  3. Okuda H, Nagao T (June 2006). "Cardiovascular malformations induced by prenatal exposure to phenobarbital in rats". Congenit Anom (Kyoto). 46 (2): 97–104. doi:10.1111/j.1741-4520.2006.00109.x. PMID 16732768.



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