Difference between revisions of "Transposition of the great vessels natural History, complications & prognosis"

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==Prognosis==
 
==Prognosis==
  
* Without treatment, 30% of infants die within the first week of life, 50% will die in the first month, 70% will die in the first 6 months and 90% of infants will die before the end of the first year.<ref name="pmid12324738">{{cite journal |vauthors=Hutter PA, Kreb DL, Mantel SF, Hitchcock JF, Meijboom EJ, Bennink GB |title=Twenty-five years' experience with the arterial switch operation |journal=J. Thorac. Cardiovasc. Surg. |volume=124 |issue=4 |pages=790–7 |date=October 2002 |pmid=12324738 |doi=10.1067/mtc.2002.120714 |url=}}</ref>
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* Without treatment, 30% of infants die within the first week of life, 50% will die in the first month, 70% will die in the first 6 months and 90% of infants will die before the end of the first year.<ref name="pmid12324738">{{cite journal |vauthors=Hutter PA, Kreb DL, Mantel SF, Hitchcock JF, Meijboom EJ, Bennink GB |title=Twenty-five years' experience with the arterial switch operation |journal=J. Thorac. Cardiovasc. Surg. |volume=124 |issue=4 |pages=790–7 |date=October 2002 |pmid=12324738 |doi=10.1067/mtc.2002.120714 |url=}}</ref><ref name="pmid20620718">{{cite journal |vauthors=Tobler D, Williams WG, Jegatheeswaran A, Van Arsdell GS, McCrindle BW, Greutmann M, Oechslin EN, Silversides CK |title=Cardiac outcomes in young adult survivors of the arterial switch operation for transposition of the great arteries |journal=J. Am. Coll. Cardiol. |volume=56 |issue=1 |pages=58–64 |date=June 2010 |pmid=20620718 |doi=10.1016/j.jacc.2010.03.031 |url=}}</ref>
 
*The prognosis for patients with D-TGA is generally excellent following surgical correction.
 
*The prognosis for patients with D-TGA is generally excellent following surgical correction.
 
*Current survival rates are greater than 90%.  
 
*Current survival rates are greater than 90%.  

Revision as of 17:45, 21 February 2020

Transposition of the great vessels Microchapters

Home

Patient Information

Overview

Historical perspective

Classification

Dextro-transposition of the great arteries
L-transposition of the great arteries

Pathophysiology

Causes

Differentiating Transposition of the great vessels from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]; Keri Shafer, M.D. [4]; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. [5]

Overview

Natural History

Complications

Common complications of TGA include:[1]

Prognosis

  • Without treatment, 30% of infants die within the first week of life, 50% will die in the first month, 70% will die in the first 6 months and 90% of infants will die before the end of the first year.[2][3]
  • The prognosis for patients with D-TGA is generally excellent following surgical correction.
  • Current survival rates are greater than 90%.
  • The ASO has the best long-term survival and functional outcome.
  • Studies have reported a >95% rate survival at fifteen to twenty-five years following discharge.
  • The prognosis on simple d-TGA depends mainly on the presence of cardiac shunts such as FO, ASD, VSD, and DA.
    • Presence of one or more of the above mentioned defects are present, blood will be mixed, allowing a small amount of oxygen to be delivered to the body, giving an opportunity to the newborn to survive long enough to receive corrective surgery.

References

  1. Gatzoulis MA, Walters J, McLaughlin PR, Merchant N, Webb GD, Liu P (October 2000). "Late arrhythmia in adults with the mustard procedure for transposition of great arteries: a surrogate marker for right ventricular dysfunction?". Heart. 84 (4): 409–15. doi:10.1136/heart.84.4.409. PMC 1729461. PMID 10995411.
  2. Hutter PA, Kreb DL, Mantel SF, Hitchcock JF, Meijboom EJ, Bennink GB (October 2002). "Twenty-five years' experience with the arterial switch operation". J. Thorac. Cardiovasc. Surg. 124 (4): 790–7. doi:10.1067/mtc.2002.120714. PMID 12324738.
  3. Tobler D, Williams WG, Jegatheeswaran A, Van Arsdell GS, McCrindle BW, Greutmann M, Oechslin EN, Silversides CK (June 2010). "Cardiac outcomes in young adult survivors of the arterial switch operation for transposition of the great arteries". J. Am. Coll. Cardiol. 56 (1): 58–64. doi:10.1016/j.jacc.2010.03.031. PMID 20620718.




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