Difference between revisions of "Thebaine"

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Template:Chembox E number
IUPAC name 6,7,8,14-tetradehydro-4,5a-epoxy-
Other names Paramorphine
3D model (JSmol)
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MeSH Thebaine
Molar mass 311.37 g/mol
Metabolism O-demethylation via CYP450 2D6[1]
Legal status

Class A(UK) Schedule II(US)

Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Thebaine (paramorphine) is an opiate alkaloid. A minor constituent of opium, thebaine is chemically similar to both morphine and codeine, but has stimulatory rather than depressant effects, causing strychnine-like convulsions. Thebaine is not used therapeutically, but is converted industrially into a variety of compounds including oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone, buprenorphine and etorphine.

It is controlled in Schedule II of the Controlled Substances Act as well as under international law. Thebaine is listed as a Class A drug under the Misuse of Drugs Act 1971 in the United Kingdom.


  1. Mikus G, Somogyi AA, Bochner F, Eichelbaum M. "Thebaine O-demethylation to oripavine: genetic differences between two rat strains." Xenobiotica. 1991 Nov; 21(11):1501-9. PMID 1763524
  2. WHO Advisory Group. "The dependence potential of thebaine." Bulletin on Narcotics. 1980; 32(1):45–54. Accessed October 5 2007. PMID 6778542


de:Thebain it:Tebaina no:Tebain sv:Tebain th:ทีบาอีน