Tau-protein kinase

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In enzymology, a tau-protein kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + [tau-protein] ADP + O-phospho-[tau-protein]

Thus, the two substrates of this enzyme are ATP and tau-protein, whereas its two products are ADP and O-phospho-tau-protein.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[tau-protein] O-phosphotransferase. Other names in common use include ATP:tau-protein O-hosphotransferase, brain protein kinase PK40erk, cdk5/p20, CDK5/p23, glycogen synthase kinase-3beta, GSK, protein tau kinase, STK31, tau kinase, [tau-protein] kinase, tau-protein kinase I, tau-protein kinase II, tau-tubulin kinase, TPK, TPK I, TPK II, and TTK. This enzyme participates in 14 metabolic pathways: erbb signaling pathway, cell cycle, wnt signaling pathway, hedgehog signaling pathway, axon guidance, focal adhesion, b cell receptor signaling pathway, insulin signaling pathway, melanogenesis, alzheimer's disease, colorectal cancer, endometrial cancer, prostate cancer, and basal cell carcinoma.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2JDO, 2JDR, and 2UW9.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Ishiguro K, Ihara Y, Uchida T, Imahori K (Tokyo). "A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau". J. Biochem.: 319&ndash, 21. PMID 2467901. Check date values in: |date= (help)
  • Lund ET, McKenna R, Evans DB, Sharma SK, Mathews WR (2001). "Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry". J. Neurochem. 76: 1221&ndash, 32. PMID 11181841.
  • Takashima A (1998). "Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells". Biochim. Biophys. Acta. 1380: 177&ndash, 82. PMID 9565682.
  • Sugio S, Kohno T, Matsuzaki T (Pt 11). "Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3beta". Acta. Crystallogr. D. Biol. Crystallogr. 56: 1464&ndash, 5. PMID 11053853. Check date values in: |date= (help)

External links

The CAS registry number for this enzyme class is 111694-09-8.

Gene Ontology (GO) codes