SLC19A2

Revision as of 06:27, 11 September 2017 by KolbertBot (talk) (Bot: HTTP→HTTPS)
Jump to: navigation, search
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Thiamine transporter 1, also known as thiamine carrier 1 (TC1) or solute carrier family 19 member 2 (SLC19A2) is a protein that in humans is encoded by the SLC19A2 gene.[1][2][3] SLC19A2 is a thiamine transporter.

In melanocytic cells SLC19A2 gene expression may be regulated by MITF.[4]

Clinical significance

Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness.[5]

References

  1. "Entrez Gene: solute carrier family 19 (thiamine transporter)".
  2. Neufeld EJ; Mandel H; Raz T; Szargel R; Yandava CN; Stagg A; Fauré S; Barrett T; Buist N; Cohen N (December 1997). "Localization of the gene for thiamine-responsive megaloblastic anemia syndrome, on the long arm of chromosome 1, by homozygosity mapping". Am. J. Hum. Genet. 61 (6): 1335–41. doi:10.1086/301642. PMC 1716091. PMID 9399900.
  3. Labay V; Raz T; Baron D; Mandel H; Williams H; Barrett T; Szargel R; McDonald L; Shalata A; Nosaka K; Gregory S; Cohen N (July 1999). "Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness". Nat. Genet. 22 (3): 300–4. doi:10.1038/10372. PMID 10391221.
  4. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
  5. Bay A; Keskin M; Hizli S; Uygun H; Dai A; Gumruk F (October 2010). "Thiamine-responsive megaloblastic anemia syndrome". Int. J. Hematol. 92 (3): 524–6. doi:10.1007/s12185-010-0681-y. PMID 20835854.

Further reading

External links



Linked-in.jpg