Difference between revisions of "RHOB"

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{{protein
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{{About|the ras homolog gene family|the Rayburn House Office Building|Rayburn House Office Building}}
|Name=ras homolog gene family, member B
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|caption=
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{{Infobox_gene}}
|image=
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'''Ras homolog gene family, member B''', also known as '''RHOB''', is a [[protein]] which in humans is encoded by the ''RHOB'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RHOB ras homolog gene family, member B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=388| accessdate = }}</ref><ref name="pmid3283705">{{cite journal |vauthors=Chardin P, Madaule P, Tavitian A | title = Coding sequence of human rho cDNAs clone 6 and clone 9 | journal = Nucleic Acids Research | volume = 16 | issue = 6 | pages = 2717 |date=March 1988 | pmid = 3283705 | pmc = 336400 | doi = 10.1093/nar/16.6.2717| url = http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=3283705 }}</ref>
|width=
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|HGNCid=668
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RHOB is a member of the [[Rho family of GTPases|Rho GTP-binding protein]] family.<ref name="pmid15020670">{{cite journal |vauthors=Wennerberg K, Der CJ | title = Rho-family GTPases: it's not only Rac and Rho (and I like it) | journal = Journal of Cell Science | volume = 117 | issue = Pt 8 | pages = 1301–12 |date=March 2004 | pmid = 15020670 | doi = 10.1242/jcs.01118 | url =  }}</ref>
|Symbol=RHOB
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|AltSymbols=ARH6, ARHB
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==Interactions==
|EntrezGene=388
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RHOB has been shown to [[Protein-protein interaction|interact]] with [[CIT (gene)|CIT]],<ref name=pmid8543060>{{cite journal |doi=10.1016/0014-5793(95)01351-2 |last=Madaule |first=P |authorlink= |author2=Furuyashiki T |author3=Reid T |author4=Ishizaki T |author5=Watanabe G |author6=Morii N |author7=Narumiya S  |date=Dec 1995 |title=A novel partner for the GTP-bound forms of rho and rac |journal=FEBS Lett. |volume=377 |issue=2 |pages=243–8 | issn = 0014-5793| pmid = 8543060 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[ARHGEF3]],<ref name=pmid12221096>{{cite journal |last=Arthur |first=William T |authorlink= |author2=Ellerbroek Shawn M |author3=Der Channing J |author4=Burridge Keith |author5=Wennerberg Krister  |date=Nov 2002 |title=XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC |journal=J. Biol. Chem. |volume=277 |issue=45 |pages=42964–72 | issn = 0021-9258| pmid = 12221096 |doi = 10.1074/jbc.M207401200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[ARHGDIG]]<ref name=pmid8939998>{{cite journal |doi=10.1074/jbc.271.48.30366 |last=Zalcman |first=G |authorlink= |author2=Closson V |author3=Camonis J |author4=Honoré N |author5=Rousseau-Merck M F |author6=Tavitian A |author7=Olofsson B  |date=Nov 1996 |title=RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG |journal=J. Biol. Chem. |volume=271 |issue=48 |pages=30366–74 | issn = 0021-9258| pmid = 8939998 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[RHPN2]].<ref name=pmid12473120>{{cite journal |doi=10.1046/j.1432-1033.2002.03343.x |last=Mircescu |first=Hortensia |authorlink= |author2=Steuve Séverine |author3=Savonet Valérie |author4=Degraef Chantal |author5=Mellor Harry |author6=Dumont Jacques E |author7=Maenhaut Carine |author8=Pirson Isabelle  |date=Dec 2002 |title=Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP |journal=Eur. J. Biochem. |volume=269 |issue=24 |pages=6241–9 | issn = 0014-2956| pmid = 12473120 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
|OMIM=165370
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|RefSeq=NM_004040
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==References==
|UniProt=P62745
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{{Reflist}}
|PDB=
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|ECnumber=
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==Further reading==
|Chromosome=2
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{{refbegin | 2}}
|Arm=p
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{{PBB_Further_reading
|Band=ter
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| citations =  
|LocusSupplementaryData=-p12
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*{{cite journal  |vauthors=Bravo-Nuevo A, Sugimoto H, etal |title=RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice. |journal= Am J Pathol |volume=178 |issue= 1 |pages= 245–252 |year= 2011 |pmid= 21224061 |doi=10.1016/j.ajpath.2010.11.040 |pmc=3069827}}
 +
*{{cite journal  |vauthors=Casey PJ, Seabra MC |title=Protein prenyltransferases. |journal=J. Biol. Chem. |volume=271 |issue= 10 |pages= 5289–92 |year= 1996 |pmid= 8621375 |doi=10.1074/jbc.271.10.5289  }}
 +
*{{cite journal  |vauthors=Adamson P, Marshall CJ, Hall A, Tilbrook PA |title=Post-translational modifications of p21rho proteins. |journal=J. Biol. Chem. |volume=267 |issue= 28 |pages= 20033–8 |year= 1992 |pmid= 1400319 |doi=  }}
 +
*{{cite journal  |vauthors=Cannizzaro LA, Madaule P, Hecht F, etal |title=Chromosome localization of human ARH genes, a ras-related gene family. |journal=Genomics |volume=6 |issue= 2 |pages= 197–203 |year= 1990 |pmid= 2407642 |doi=10.1016/0888-7543(90)90557-B  }}
 +
*{{cite journal  |vauthors=Chardin P, Madaule P, Tavitian A |title=Coding sequence of human rho cDNAs clone 6 and clone 9. |journal=Nucleic Acids Res. |volume=16 |issue= 6 |pages= 2717 |year= 1988 |pmid= 3283705 |doi=10.1093/nar/16.6.2717  | pmc=336400  }}
 +
*{{cite journal  |vauthors=Madaule P, Axel R |title=A novel ras-related gene family. |journal=Cell |volume=41 |issue= 1 |pages= 31–40 |year= 1985 |pmid= 3888408 |doi=10.1016/0092-8674(85)90058-3  }}
 +
*{{cite journal  |vauthors=Robertson D, Paterson HF, Adamson P, etal |title=Ultrastructural localization of ras-related proteins using epitope-tagged plasmids. |journal=J. Histochem. Cytochem. |volume=43 |issue= 5 |pages= 471–80 |year= 1995 |pmid= 7537292 |doi=  10.1177/43.5.7537292}}
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*{{cite journal  |vauthors=Armstrong SA, Hannah VC, Goldstein JL, Brown MS |title=CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. |journal=J. Biol. Chem. |volume=270 |issue= 14 |pages= 7864–8 |year= 1995 |pmid= 7713879 |doi=10.1074/jbc.270.14.7864  }}
 +
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
 +
*{{cite journal  |vauthors=Zalcman G, Closson V, Camonis J, etal |title=RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30366–74 |year= 1997 |pmid= 8939998 |doi=10.1074/jbc.271.48.30366  }}
 +
*{{cite journal  |vauthors=Mellor H, Flynn P, Nobes CD, etal |title=PRK1 is targeted to endosomes by the small GTPase, RhoB. |journal=J. Biol. Chem. |volume=273 |issue= 9 |pages= 4811–4 |year= 1998 |pmid= 9478917 |doi=10.1074/jbc.273.9.4811  }}
 +
*{{cite journal  |vauthors=Ishikawa K, Nagase T, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=10.1093/dnares/5.3.169  }}
 +
*{{cite journal  |vauthors=Liu JP, Jessell TM |title=A role for rhoB in the delamination of neural crest cells from the dorsal neural tube. |journal=Development |volume=125 |issue= 24 |pages= 5055–67 |year= 1999 |pmid= 9811589 |doi=  }}
 +
*{{cite journal  |vauthors=Gampel A, Parker PJ, Mellor H |title=Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB. |journal=Curr. Biol. |volume=9 |issue= 17 |pages= 955–8 |year= 2000 |pmid= 10508588 |doi=10.1016/S0960-9822(99)80422-9  }}
 +
*{{cite journal  |vauthors=Matarrese P, Conti L, Varano B, etal |title=The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly. |journal=Cell Death Differ. |volume=7 |issue= 1 |pages= 25–36 |year= 2000 |pmid= 10713718 |doi= 10.1038/sj.cdd.4400616 }}
 +
*{{cite journal  |vauthors=Liu A, Du W, Liu JP, etal |title=RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors. |journal=Mol. Cell. Biol. |volume=20 |issue= 16 |pages= 6105–13 |year= 2000 |pmid= 10913192 |doi=10.1128/MCB.20.16.6105-6113.2000  | pmc=86086  }}
 +
*{{cite journal  |vauthors=Michaelson D, Silletti J, Murphy G, etal |title=Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. |journal=J. Cell Biol. |volume=152 |issue= 1 |pages= 111–26 |year= 2001 |pmid= 11149925 |doi=10.1083/jcb.152.1.111  | pmc=2193662  }}
 +
*{{cite journal  |author1=Liu Ax |author2=Cerniglia GJ |author3=Bernhard EJ |author4=Prendergast GC |title=RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 11 |pages= 6192–7 |year= 2001 |pmid= 11353846 |doi= 10.1073/pnas.111137198  | pmc=33444 |bibcode=2001PNAS...98.6192L }}
 +
*{{cite journal  |vauthors=Diviani D, Soderling J, Scott JD |title=AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 44247–57 |year= 2001 |pmid= 11546812 |doi= 10.1074/jbc.M106629200 }}
 +
*{{cite journal  |vauthors=Adnane J, Seijo E, Chen Z, etal |title=RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8500–7 |year= 2002 |pmid= 11741970 |doi= 10.1074/jbc.M104367200 }}
 
}}
 
}}
'''RHOB''' is a member of the [[Rho GTP-binding protein]] family.
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{{refend}}
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{{PDB Gallery|geneid=388}}
  
 
==See also==
 
==See also==
 
* [[neural crest]]
 
* [[neural crest]]
  
{{biochem-stub}}
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{{GTPases}}
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{{Rho family of GTPases}}
  
{{GTPases}}
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Latest revision as of 13:49, 7 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.[1][2]

RHOB is a member of the Rho GTP-binding protein family.[3]

Interactions

RHOB has been shown to interact with CIT,[4] ARHGEF3,[5] ARHGDIG[6] and RHPN2.[7]

References

  1. "Entrez Gene: RHOB ras homolog gene family, member B".
  2. Chardin P, Madaule P, Tavitian A (March 1988). "Coding sequence of human rho cDNAs clone 6 and clone 9". Nucleic Acids Research. 16 (6): 2717. doi:10.1093/nar/16.6.2717. PMC 336400. PMID 3283705.
  3. Wennerberg K, Der CJ (March 2004). "Rho-family GTPases: it's not only Rac and Rho (and I like it)". Journal of Cell Science. 117 (Pt 8): 1301–12. doi:10.1242/jcs.01118. PMID 15020670.
  4. Madaule, P; Furuyashiki T; Reid T; Ishizaki T; Watanabe G; Morii N; Narumiya S (Dec 1995). "A novel partner for the GTP-bound forms of rho and rac". FEBS Lett. 377 (2): 243–8. doi:10.1016/0014-5793(95)01351-2. ISSN 0014-5793. PMID 8543060.
  5. Arthur, William T; Ellerbroek Shawn M; Der Channing J; Burridge Keith; Wennerberg Krister (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. ISSN 0021-9258. PMID 12221096.
  6. Zalcman, G; Closson V; Camonis J; Honoré N; Rousseau-Merck M F; Tavitian A; Olofsson B (Nov 1996). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. 271 (48): 30366–74. doi:10.1074/jbc.271.48.30366. ISSN 0021-9258. PMID 8939998.
  7. Mircescu, Hortensia; Steuve Séverine; Savonet Valérie; Degraef Chantal; Mellor Harry; Dumont Jacques E; Maenhaut Carine; Pirson Isabelle (Dec 2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP". Eur. J. Biochem. 269 (24): 6241–9. doi:10.1046/j.1432-1033.2002.03343.x. ISSN 0014-2956. PMID 12473120.

Further reading

See also




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