PiggyBac Transposable Element Derived 5

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Identifiers
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External IDsGeneCards: [1]
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SpeciesHumanMouse
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PiggyBac Transposable Element Derived 5 is an enzyme that in humans is encoded by the PGBD5 gene.[1] PGBD5 is a DNA transposase related to the ancient PiggyBac transposase first identified in the cabbage looper moth, Trichoplusia ni.[2] The gene is believed to have been domesticated over 500 million years ago in the common ancestor of cephalochordates and vertebrates.[3] Although the catalytic triad of the protein composed of three aspartic acid residues is not conserved through evolution,[3] the protein has been shown to be able to transpose DNA in a sequence-specific, cut-and-paste fashion.[4]

References

  1. "PGBD5 piggyBac transposable element derived 5 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 8 April 2017.
  2. Toman J (April 1979). "A course to pursue". Nursing Times. 75 (17): 694–5. PMC 255260.
  3. 3.0 3.1 Pavelitz T, Gray LT, Padilla SL, Bailey AD, Weiner AM (November 2013). "PGBD5: a neural-specific intron-containing piggyBac transposase domesticated over 500 million years ago and conserved from cephalochordates to humans". Mobile DNA. 4 (1): 23. doi:10.1186/1759-8753-4-23. PMID 24180413.
  4. Henssen AG, Henaff E, Jiang E, Eisenberg AR, Carson JR, Villasante CM, Ray M, Still E, Burns M, Gandara J, Feschotte C, Mason CE, Kentsis A (September 2015). "Genomic DNA transposition induced by human PGBD5". eLife. 4. doi:10.7554/eLife.10565. PMID 26406119.

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