PiggyBac Transposable Element Derived 5 is an enzyme that in humans is encoded by the PGBD5gene. PGBD5 is a DNA transposase related to the ancient PiggyBac transposase first identified in the cabbage looper moth, Trichoplusia ni. The gene is believed to have been domesticated over 500 million years ago in the common ancestor of cephalochordates and vertebrates. Although the catalytic triad of the protein composed of three aspartic acid residues is not conserved through evolution, the protein has been shown to be able to transpose DNA in a sequence-specific, cut-and-paste fashion.
↑ 3.03.1Pavelitz T, Gray LT, Padilla SL, Bailey AD, Weiner AM (November 2013). "PGBD5: a neural-specific intron-containing piggyBac transposase domesticated over 500 million years ago and conserved from cephalochordates to humans". Mobile DNA. 4 (1): 23. doi:10.1186/1759-8753-4-23. PMID24180413.
↑Henssen AG, Henaff E, Jiang E, Eisenberg AR, Carson JR, Villasante CM, Ray M, Still E, Burns M, Gandara J, Feschotte C, Mason CE, Kentsis A (September 2015). "Genomic DNA transposition induced by human PGBD5". eLife. 4. doi:10.7554/eLife.10565. PMID26406119.