Difference between revisions of "PIP5K1A"

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'''Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha''' is an [[enzyme]] that in humans is encoded by the ''PIP5K1A'' [[gene]].<ref name="pmid8955136">{{cite journal | vauthors = Loijens JC, Anderson RA | title = Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family | journal = J Biol Chem | volume = 271 | issue = 51 | pages = 32937–43 |date=Jan 1997 | pmid = 8955136 | pmc =  | doi =10.1074/jbc.271.51.32937 }}</ref><ref name="pmid10828584">{{cite journal | vauthors = Xie Y, Zhu L, Zhao G | title = Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 88 | issue = 3-4 | pages = 197–9 |date=Jun 2000 | pmid = 10828584 | pmc =  | doi =10.1159/000015545 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8394| accessdate = }}</ref>
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{{GNF_Protein_box
 
| image =
 
| image_source =
 
| PDB =
 
| Name = Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
 
| HGNCid = 8994
 
| Symbol = PIP5K1A
 
| AltSymbols =;
 
| OMIM = 603275
 
| ECnumber =
 
| Homologene = 20787
 
| MGIid = 107929
 
  | GeneAtlas_image1 = PBB_GE_PIP5K1A_207391_s_at_tn.png
 
| GeneAtlas_image2 = PBB_GE_PIP5K1A_210256_s_at_tn.png
 
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016308 |text = 1-phosphatidylinositol-4-phosphate 5-kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
 
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0016020 |text = membrane}}
 
  | Process = {{GNF_GO|id=GO:0006650 |text = glycerophospholipid metabolic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016310 |text = phosphorylation}} {{GNF_GO|id=GO:0046488 |text = phosphatidylinositol metabolic process}}
 
| Orthologs = {{GNF_Ortholog_box
 
    | Hs_EntrezGene = 8394
 
    | Hs_Ensembl = ENSG00000143398
 
    | Hs_RefseqProtein = NP_003548
 
    | Hs_RefseqmRNA = NM_003557
 
    | Hs_GenLoc_db = 
 
    | Hs_GenLoc_chr = 1
 
    | Hs_GenLoc_start = 149437651
 
    | Hs_GenLoc_end = 149488636
 
    | Hs_Uniprot = Q99755
 
    | Mm_EntrezGene = 18720
 
    | Mm_Ensembl = ENSMUSG00000028126
 
    | Mm_RefseqmRNA = NM_008847
 
    | Mm_RefseqProtein = NP_032873
 
    | Mm_GenLoc_db =   
 
    | Mm_GenLoc_chr = 3
 
    | Mm_GenLoc_start = 95145888
 
    | Mm_GenLoc_end = 95191855
 
    | Mm_Uniprot = Q3U917
 
  }}
 
}}
 
'''Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha''', also known as '''PIP5K1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8394| accessdate = }}</ref>
 
  
 
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==References==
 
==References==
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==Further reading==
 
==Further reading==
 
{{refbegin | 2}}
 
{{refbegin | 2}}
 
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| citations =  
 
| citations =  
*{{cite journal | author=Loijens JC, Anderson RA |title=Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. |journal=J. Biol. Chem. |volume=271 |issue= 51 |pages= 32937-43 |year= 1997 |pmid= 8955136 |doi=  }}
+
*{{cite journal   |vauthors=Honda A, Nogami M, Yokozeki T, etal |title=Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. |journal=Cell |volume=99 |issue= 5 |pages= 521–32 |year= 1999 |pmid= 10589680 |doi=10.1016/S0092-8674(00)81540-8 }}
*{{cite journal  | author=Honda A, Nogami M, Yokozeki T, ''et al.'' |title=Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. |journal=Cell |volume=99 |issue= 5 |pages= 521-32 |year= 1999 |pmid= 10589680 |doi=  }}
+
*{{cite journal   |vauthors=Jones DH, Morris JB, Morgan CP, etal |title=Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment. |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13962–6 |year= 2000 |pmid= 10747863 |doi=10.1074/jbc.C901019199 }}
*{{cite journal | author=Jones DH, Morris JB, Morgan CP, ''et al.'' |title=Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment. |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13962-6 |year= 2000 |pmid= 10747863 |doi= }}
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*{{cite journal   |vauthors=Divecha N, Roefs M, Halstead JR, etal |title=Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. |journal=EMBO J. |volume=19 |issue= 20 |pages= 5440–9 |year= 2000 |pmid= 11032811 |doi= 10.1093/emboj/19.20.5440 | pmc=314009 }}
*{{cite journal  | author=Xie Y, Zhu L, Zhao G |title=Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 197-9 |year= 2000 |pmid= 10828584 |doi= }}
+
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Divecha N, Roefs M, Halstead JR, ''et al.'' |title=Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. |journal=EMBO J. |volume=19 |issue= 20 |pages= 5440-9 |year= 2000 |pmid= 11032811 |doi= 10.1093/emboj/19.20.5440 }}
+
*{{cite journal   |vauthors=Doughman RL, Firestone AJ, Wojtasiak ML, etal |title=Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 23036–45 |year= 2003 |pmid= 12682053 |doi= 10.1074/jbc.M211397200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+
*{{cite journal   |vauthors=Chang JD, Field SJ, Rameh LE, etal |title=Identification and characterization of a phosphoinositide phosphate kinase homolog. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11672–9 |year= 2004 |pmid= 14701839 |doi= 10.1074/jbc.M309721200 }}
*{{cite journal | author=Doughman RL, Firestone AJ, Wojtasiak ML, ''et al.'' |title=Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 23036-45 |year= 2003 |pmid= 12682053 |doi= 10.1074/jbc.M211397200 }}
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*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Chang JD, Field SJ, Rameh LE, ''et al.'' |title=Identification and characterization of a phosphoinositide phosphate kinase homolog. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11672-9 |year= 2004 |pmid= 14701839 |doi= 10.1074/jbc.M309721200 }}
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*{{cite journal   |vauthors=Kisseleva M, Feng Y, Ward M, etal |title=The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. |journal=Mol. Cell. Biol. |volume=25 |issue= 10 |pages= 3956–66 |year= 2005 |pmid= 15870270 |doi= 10.1128/MCB.25.10.3956-3966.2005 | pmc=1087706 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Kisseleva M, Feng Y, Ward M, ''et al.'' |title=The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. |journal=Mol. Cell. Biol. |volume=25 |issue= 10 |pages= 3956-66 |year= 2005 |pmid= 15870270 |doi= 10.1128/MCB.25.10.3956-3966.2005 }}
+
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
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*{{cite journal   |vauthors=Halstead JR, van Rheenen J, Snel MH, etal |title=A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. |journal=Curr. Biol. |volume=16 |issue= 18 |pages= 1850–6 |year= 2006 |pmid= 16979564 |doi= 10.1016/j.cub.2006.07.066 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
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*{{cite journal   |vauthors=Im YJ, Perera IY, Brglez I, etal |title=Increasing plasma membrane phosphatidylinositol(4,5)bisphosphate biosynthesis increases phosphoinositide metabolism in Nicotiana tabacum. |journal=Plant Cell |volume=19 |issue= 5 |pages= 1603–16 |year= 2007 |pmid= 17496116 |doi= 10.1105/tpc.107.051367 | pmc=1913725 }}
*{{cite journal | author=Halstead JR, van Rheenen J, Snel MH, ''et al.'' |title=A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. |journal=Curr. Biol. |volume=16 |issue= 18 |pages= 1850-6 |year= 2006 |pmid= 16979564 |doi= 10.1016/j.cub.2006.07.066 }}
 
*{{cite journal | author=Im YJ, Perera IY, Brglez I, ''et al.'' |title=Increasing plasma membrane phosphatidylinositol(4,5)bisphosphate biosynthesis increases phosphoinositide metabolism in Nicotiana tabacum. |journal=Plant Cell |volume=19 |issue= 5 |pages= 1603-16 |year= 2007 |pmid= 17496116 |doi= 10.1105/tpc.107.051367 }}
 
 
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Latest revision as of 18:10, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene.[1][2][3]


References

  1. Loijens JC, Anderson RA (Jan 1997). "Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family". J Biol Chem. 271 (51): 32937–43. doi:10.1074/jbc.271.51.32937. PMID 8955136.
  2. Xie Y, Zhu L, Zhao G (Jun 2000). "Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization". Cytogenet Cell Genet. 88 (3–4): 197–9. doi:10.1159/000015545. PMID 10828584.
  3. "Entrez Gene: PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha".

Further reading




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