Methylprednisolone detailed information

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Methylprednisolone detailed information
File:Methylprednisolone.svg
Clinical data
Pregnancy
category
  • C
Routes of
administration
IV, IM, IV Infusion, oral
ATC code
Pharmacokinetic data
Protein binding78%
Metabolismliver primarily, kidney, tissues; CYP450: 3A4 substrate
Elimination half-lifeurine; Half-life: 18-26h (biological)
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
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Chemical and physical data
FormulaC22H30O5
Molar mass374.471 g/mol

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Methylprednisolone (molecular weight 374.48) is a synthetic glucocorticoid drug taken orally or administered intraveinously. Its chemical name is pregna-1,4-diene-3,20 -dione, 11,17,21-trihydroxy-6-methyl-,(6α, 11β)- and its chemical formula is C22H30O5. Methylprednisolone is sold in the USA and Canada under the brand name Medrol.

Like most adrenocortical steroids, methylprednisolone is typically used for its anti-inflammatory purposes. However, glucocorticoids have a wide range of effects, including changes to metabolism and immune responses. The list of medical conditions for which methlyprednisolone is prescribed is rather large, and is similar to other corticosteroids such as prednisolone. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. It is used both in the treatment of acute periods and long-term controlling of autoimmune diseases, most notably SLE.

Methylprednisolone has serious side effects if taken long-term, including weight gain, glaucoma, osteoporosis and psychosis, especially when overdosed. The most serious side effect occurs after the adrenal glands cease natural production of cortisone, which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as Addisonian crisis, which can be fatal. To prevent this, the drug is usually prescribed with a tapering dosage, including a pre-dosed "dose pack" detailing a specific number of pills to take at designated times over a six day period.

Alternative treatments to many of the conditions currently indicated for methlyprednisolone are actively being researched. Additionally, new drugs such as budesonide are being created, which provide similar benefits but without the adrenal suppression problems.

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| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Methylprednisolone detailed information | list6 = US National Guidelines Clearinghouse on Methylprednisolone detailed informationNICE Guidance on Methylprednisolone detailed informationNHS PRODIGY GuidanceFDA on Methylprednisolone detailed informationCDC on Methylprednisolone detailed information


| group7 = Textbook Information on Methylprednisolone detailed information | list7 = Books and Textbook Information on Methylprednisolone detailed information


| group8 = Pharmacology Resources on Methylprednisolone detailed information | list8 = AND (Dose)}} Dosing of Methylprednisolone detailed informationAND (drug interactions)}} Drug interactions with Methylprednisolone detailed informationAND (side effects)}} Side effects of Methylprednisolone detailed informationAND (Allergy)}} Allergic reactions to Methylprednisolone detailed informationAND (overdose)}} Overdose information on Methylprednisolone detailed informationAND (carcinogenicity)}} Carcinogenicity information on Methylprednisolone detailed informationAND (pregnancy)}} Methylprednisolone detailed information in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Methylprednisolone detailed information


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Methylprednisolone detailed information | list9 = AND (pharmacogenomics)}} Genetics of Methylprednisolone detailed informationAND (pharmacogenomics)}} Pharmacogenomics of Methylprednisolone detailed informationAND (proteomics)}} Proteomics of Methylprednisolone detailed information


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| group11 = Commentary on Methylprednisolone detailed information | list11 = Blogs on Methylprednisolone detailed information

| group12 = Patient Resources on Methylprednisolone detailed information | list12 = Patient resources on Methylprednisolone detailed informationDiscussion groups on Methylprednisolone detailed informationPatient Handouts on Methylprednisolone detailed informationDirections to Hospitals Treating Methylprednisolone detailed informationRisk calculators and risk factors for Methylprednisolone detailed information


| group13 = Healthcare Provider Resources on Methylprednisolone detailed information | list13 = Symptoms of Methylprednisolone detailed informationCauses & Risk Factors for Methylprednisolone detailed informationDiagnostic studies for Methylprednisolone detailed informationTreatment of Methylprednisolone detailed information

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| group17 = Informatics Resources on Methylprednisolone detailed information | list17 = List of terms related to Methylprednisolone detailed information


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