Difference between revisions of "MAS1"

Jump to: navigation, search
(converted redirect into gene/protein specific page)
 
m (1 revision(s))
(No difference)

Revision as of 17:17, 18 December 2007


MAS1 oncogene
Identifiers
Symbols MAS1 ; MAS; MGC119966
External IDs OMIM: 165180 MGI96918 HomoloGene1782
RNA expression pattern
File:PBB GE MAS1 208210 at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 4142
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 17171

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000130368
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000068037

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| P04201
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q0VB49

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_002377 (mRNA)
NP_002368 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |XM_622557 (mRNA)
XP_622557 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 6: 160.25 - 160.25 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 17: 12.68 -  12.69 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

MAS1 oncogene, also known as MAS1, is a human gene.[1]

The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.[1]

See also

References

  1. 1.0 1.1 "Entrez Gene: MAS1 MAS1 oncogene".

Further reading

  • Hanley MR (1992). "Molecular and cell biology of angiotensin receptors". J. Cardiovasc. Pharmacol. 18 Suppl 2: S7–13. PMID 1725048.
  • Hanley MR, Cheung WT, Hawkins P; et al. (1990). "The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action". Ciba Found. Symp. 150: 23–38, discussion 38-46. PMID 2197067.
  • Rabin M, Birnbaum D, Young D; et al. (1988). "Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements". Oncogene Res. 1 (2): 169–78. PMID 3329713.
  • Jackson TR, Blair LA, Marshall J; et al. (1988). "The mas oncogene encodes an angiotensin receptor". Nature. 335 (6189): 437–40. doi:10.1038/335437a0. PMID 3419518.
  • Young D, Waitches G, Birchmeier C; et al. (1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell. 45 (5): 711–9. PMID 3708691.
  • Riesewijk AM, Schepens MT, Mariman EM; et al. (1996). "The MAS proto-oncogene is not imprinted in humans". Genomics. 35 (2): 380–2. doi:10.1006/geno.1996.0372. PMID 8661154.
  • Xu X, Quiambao AB, Roveri L; et al. (2000). "Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene". Exp. Neurol. 163 (1): 207–19. doi:10.1006/exnr.2000.7370. PMID 10785460.
  • Alenina N, Baranova T, Smirnow E; et al. (2002). "Cell type-specific expression of the Mas proto-oncogene in testis". J. Histochem. Cytochem. 50 (5): 691–6. PMID 11967280.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Santos RA, Simoes e Silva AC, Maric C; et al. (2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8258–63. doi:10.1073/pnas.1432869100. PMID 12829792.
  • Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Canals M, Jenkins L, Kellett E, Milligan G (2006). "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS". J. Biol. Chem. 281 (24): 16757–67. doi:10.1074/jbc.M601121200. PMID 16611642.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Linked-in.jpg