Leukopoiesis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]



Leukopoiesis is a form of haematopoiesis in which white blood cells (WBC, or leukocytes) are formed in the bone marrow. WBCs arise from the maturation of hemocytoblasts, which are the general stem cell for all blood cells and platelets, into various pluripotential stem cells which can then further differentiate into the different classes of WBCs.

Myeloid Stem Cell Productions

This stem cell will differentiate into either a proerythroblast (and eventually a red blood cell) or a progenitor cell. The progenitor cell will differentiate into a megakaryocyte (and then a platelet), or a myeloblast or monoblast.

Myeloblast Productions

These differentiate into 3 different types of myelocytes, which become band cells. These 3 types of band cells eventually mature into Basophils, Eosinophils, and Neutrophils.

Monoblast Productions

monoblasts differentriate into promonocytes, which mature into monocytes. Monocytes eventually enter the tissues and become Macrophages.

Lymphoid Stem Cell Productions

Lymphoid stem cells mature into lymphoblasts, and then prolymphocytes, and finally mature lymphocytes, either a B or T cell.

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