Difference between revisions of "GNA13"

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'''Guanine nucleotide binding protein (G protein), alpha 13''', also known as '''GNA13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10672| accessdate = }}</ref>
 
'''Guanine nucleotide binding protein (G protein), alpha 13''', also known as '''GNA13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10672| accessdate = }}</ref>

Revision as of 15:24, 9 August 2012


Guanine nucleotide binding protein (G protein), alpha 13
PBB Protein GNA13 image.jpg
Identifiers
Symbols GNA13 ; G13; MGC46138
External IDs OMIM: 604406 MGI95768 HomoloGene55976
RNA expression pattern
PBB GE GNA13 206917 at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 10672
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 14674

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000120063
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000020611

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q14344
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q3UE40

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_006572 (mRNA)
NP_006563 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_010303 (mRNA)
NP_034433 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 17: 60.44 - 60.48 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 11: 109.18 -  109.21 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

WikiDoc Resources for GNA13

Articles

Most recent articles on GNA13

Most cited articles on GNA13

Review articles on GNA13

Articles on GNA13 in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on GNA13

Images of GNA13

Photos of GNA13

Podcasts & MP3s on GNA13

Videos on GNA13

Evidence Based Medicine

Cochrane Collaboration on GNA13

Bandolier on GNA13

TRIP on GNA13

Clinical Trials

Ongoing Trials on GNA13 at Clinical Trials.gov

Trial results on GNA13

Clinical Trials on GNA13 at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on GNA13

NICE Guidance on GNA13

NHS PRODIGY Guidance

FDA on GNA13

CDC on GNA13

Books

Books on GNA13

News

GNA13 in the news

Be alerted to news on GNA13

News trends on GNA13

Commentary

Blogs on GNA13

Definitions

Definitions of GNA13

Patient Resources / Community

Patient resources on GNA13

Discussion groups on GNA13

Patient Handouts on GNA13

Directions to Hospitals Treating GNA13

Risk calculators and risk factors for GNA13

Healthcare Provider Resources

Symptoms of GNA13

Causes & Risk Factors for GNA13

Diagnostic studies for GNA13

Treatment of GNA13

Continuing Medical Education (CME)

CME Programs on GNA13

International

GNA13 en Espanol

GNA13 en Francais

Business

GNA13 in the Marketplace

Patents on GNA13

Experimental / Informatics

List of terms related to GNA13


Guanine nucleotide binding protein (G protein), alpha 13, also known as GNA13, is a human gene.[1]


See also

References

  1. "Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13".

Further reading

  • Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Liya Yin, Xu SM, and Coughlin SR (2005). "Essential role for Galpha 13 in endothelial cells during embryonic development". Proc. Natl. Acad. Sci. U.S.A. 102 (22): 8281–8286. doi:10.1073/pnas.0503326102. PMID 15919816.
  • Downes GB, Gautam N (2000). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
  • Kabouridis PS, Waters ST, Escobar S; et al. (1995). "Expression of GTP-binding protein alpha subunits in human thymocytes". Mol. Cell. Biochem. 144 (1): 45–51. PMID 7791744.
  • Offermanns S, Laugwitz KL, Spicher K, Schultz G (1994). "G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets". Proc. Natl. Acad. Sci. U.S.A. 91 (2): 504–8. PMID 8290554.
  • Laugwitz KL, Allgeier A, Offermanns S; et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. PMID 8552586.
  • Offermanns S, Hu YH, Simon MI (1996). "Galpha12 and galpha13 are phosphorylated during platelet activation". J. Biol. Chem. 271 (42): 26044–8. PMID 8824244.
  • Offermanns S, Mancino V, Revel JP, Simon MI (1997). "Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency". Science. 275 (5299): 533–6. PMID 8999798.
  • Macrez-Leprêtre N, Kalkbrenner F, Morel JL; et al. (1997). "G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes". J. Biol. Chem. 272 (15): 10095–102. PMID 9092554.
  • Hart MJ, Jiang X, Kozasa T; et al. (1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science. 280 (5372): 2112–4. PMID 9641916.
  • Fukuhara S, Murga C, Zohar M; et al. (1999). "A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho". J. Biol. Chem. 274 (9): 5868–79. PMID 10026210.
  • Becker KP, Garnovskaya M, Gettys T, Halushka PV (1999). "Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling". Biochim. Biophys. Acta. 1450 (3): 288–96. PMID 10395940.
  • Windh RT, Lee MJ, Hla T; et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. PMID 10488065.
  • Brydon L, Roka F, Petit L; et al. (2000). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins". Mol. Endocrinol. 13 (12): 2025–38. PMID 10598579.
  • Bhattacharyya R, Wedegaertner PB (2000). "Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding". J. Biol. Chem. 275 (20): 14992–9. doi:10.1074/jbc.M000415200. PMID 10747909.
  • Vaiskunaite R, Adarichev V, Furthmayr H; et al. (2000). "Conformational activation of radixin by G13 protein alpha subunit". J. Biol. Chem. 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.
  • Shi CS, Sinnarajah S, Cho H; et al. (2000). "G13alpha-mediated PYK2 activation. PYK2 is a mediator of G13alpha -induced serum response element-dependent transcription". J. Biol. Chem. 275 (32): 24470–6. doi:10.1074/jbc.M908449199. PMID 10821841.
  • Ponimaskin E, Behn H, Adarichev V; et al. (2000). "Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation". FEBS Lett. 478 (1–2): 173–7. PMID 10922491.
  • Jin S, Exton JH (2000). "Activation of RhoA by association of Galpha(13) with Dbl". Biochem. Biophys. Res. Commun. 277 (3): 718–21. doi:10.1006/bbrc.2000.3744. PMID 11062019.
  • Fukuhara S, Chikumi H, Gutkind JS (2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. 485 (2–3): 183–8. PMID 11094164.
  • Meigs TE, Fields TA, McKee DD, Casey PJ (2001). "Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 519–24. doi:10.1073/pnas.021350998. PMID 11136230.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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